Contrary to recent claims, in vitro evidence has been obtained to establish that Concanavalin A (Con A) is not a ferritin. Four techniques including immunoprecipitation, gel filtration, sucrose density gradient ultracentrifugation and CsCl centrifugation were employed. None of them showed that Con A is a ferritin.
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Toxicol Appl Pharmacol
December 2024
Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang of Jiangxi, No. 1 Minde Road, Nanchang, Jiangxi 330006, China. Electronic address:
Background: Ferroptosis is a key process in doxorubicin (DOX)-induced cardiotoxicity and is a potentially important therapeutic target. Thymoquinone (TQ) is a monoterpenoid compound isolated from black cumin extract that exhibits antitumor effects and acts as a powerful mitochondrial-targeted antioxidant. In this study, we investigated the effect of TQ on DOX-induced cardiotoxicity and the potential underlying mechanisms.
View Article and Find Full Text PDFAnim Nutr
December 2024
College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
The purpose of this study was to gain insight into the mechanism of iron dextran (DexFe) absorption in the intestines. A total of 72 piglets (average BW = 7.12 ± 0.
View Article and Find Full Text PDFBiomedica
August 2024
Hospital Regional de Alta Especialidad Ixtapaluca, IMSS-BIENESTAR, Ciudad de México, México.
Introduction: Data on the prevalence of fungal coinfections/superinfections in patients with COVID-19 are limited.
Objective: To describe the prevalence of fungal coinfections/superinfections in patients with COVID-19, as well as risk factors and demographic, clinical, and microbiological characteristics.
Material And Methods: We included patients with a confirmed COVID-19 diagnosis and a confirmed fungal infection hospitalized in the ICU from March 2020 to December 2021.
J Clin Med
August 2024
Department of Radiology, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, Italy.
: This multicenter, retrospective, population-based, matched-cohort study compared clinical characteristics and magnetic resonance imaging (MRI) findings, including hepatic, pancreatic, and cardiac iron levels and cardiac function, between 135 adult regularly transfused thalassemia intermedia (TI) patients (44.73 ± 12.16 years, 77 females) and 135 age- and sex-matched thalassemia major (TM) patients (43.
View Article and Find Full Text PDFEcotoxicol Environ Saf
October 2024
College of Veterinary Medicine, China Agricultural University, Haidian, Beijing 100193, China. Electronic address:
One of the ways Aflatoxin B1 damages the liver is through ferroptosis. Ferroptosis is characterized by the build-up of lipid peroxides and reactive oxygen species (ROS) due to an excess of iron. Dietary supplements have emerged as a promising strategy for treating ferroptosis in the liver.
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