Requirement of signal peptidase ComC and thiol-disulfide oxidoreductase DsbA for optimal cell surface display of pseudopilin ComGC in Staphylococcus aureus.

Magdalena M van der Kooi-Pol Ewoud Reilman Mark J J B Sibbald Yanka K Veenstra-Kyuchukova Thijs R H M Kouwen Girbe Buist Jan Maarten van Dijl

Appl Environ Microbiol

Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Published: October 2012

Staphylococcus aureus is a key Gram-positive bacterium known for its various harmful factors.
The study highlights the importance of the DsbA enzyme in forming the ComGC pseudopilin, which is crucial for the bacterium's structure.
Additionally, the enzyme ComC is necessary for the proper development and visibility of ComGC on the bacterial surface.

Staphylococcus aureus is an important Gram-positive bacterial pathogen producing many secreted and cell surface-localized virulence factors. Here we report that the staphylococcal thiol-disulfide oxidoreductase DsbA is essential for stable biogenesis of the ComGC pseudopilin. The signal peptidase ComC is indispensable for ComGC maturation and optimal cell surface exposure.

Download full-text PDF	Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457507	PMC
http://dx.doi.org/10.1128/AEM.01565-12	DOI Listing

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