Glycosides, clausenosides A and B, and carbazole alkaloids, clausenaline A, claulamine A, and claulamine B, together with 50 known compounds, were isolated from the stems of Clausena lansium. Their structures were determined by means of spectroscopic methods, including that of CD and 1D/2D NMR analysis. Claulamine A has a 1-oxygenated carbazole skeleton with a rare 2,3-lactone ring, and claulamine B represents an hitherto unknown acetal carbazole alkaloid. Thirty-one of the isolated known compounds were evaluated in various assays for anti-inflammatory activity. Among them, imperatorin, isoheraclenin, and osthol exhibited selective and potent inhibition of formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation, and lansiumarin C also decreased nitric oxide (NO) and tumor necrosis factor-α (TNF-α) production in lipopolysaccharide (LPS)-induced macrophages. In addition, a modified HPLC method of pre-column derivatization was developed that is more practical for simultaneous analysis of aldose enantiomers as compared to the literature method. The absolute configurations of the sugar moieties in clausenosides A and B were determined with this modified method.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.phytochem.2012.06.019 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Study on the Chemical Composition and Anti-Tumor Mechanisms of Fruit By-Products: Based on LC-MS, Network Pharmacology Analysis, and Protein Target Validation.
Foods
November 2024
Teaching and Experimental Center, Guangdong Pharmaceutical University, Guangzhou 510006, China.
(Lour.) Skeels, commonly known as Wampee, are valued for their edible and medicinal qualities, yet their pericarp and seeds are often discarded, resulting in wasted resources. This study investigates the anti-tumor potential of these by-products, focusing on their chemical composition and underlying mechanisms of action.
View Article and Find Full Text PDFPurification, structural identification, in vitro hypoglycemic activity and digestion characteristics of polysaccharides from the flesh and peel of wampee (Clausena lansium).
Food Res Int
December 2024
College of Life Science, Yangtze University, Jingzhou, Hubei, 434023, PR China. Electronic address:
In this study, two polysaccharides were isolated from the flesh and peel of wampee, termed as PWP-F and PWP-P respectively, and their structural characteristics, in vitro antioxidant and hypoglycemic activities and digestion were investigated. Results indicated the molecular weight of PWP-F was higher than that of PWP-P and they were both mainly composed of galactose and arabinose. Both polysaccharides exhibited α-type and β-type glycosidic linkages based on FTIR analysis.
View Article and Find Full Text PDFEffects of Clausena lansium leaves volatile oil emulsion against Staphylococcus aureus in mice via autophagy modulation.
Phytomedicine
December 2024
School of Life Science and Engineering, Foshan University, Foshan 528225, China. Electronic address:
Background: Volatile oil from fresh Clausena lansium (Lour.) Skeels (Rutaceae) (common name Wampee) has been previously extracted by our group from fresh C. lansium leaf and its components were qualitative and quantitatively analyzed by GC-MS.
View Article and Find Full Text PDFInsights into Tissue-Specific Specialized Metabolism in Wampee ( (Lour.) Skeels) Varieties.
Foods
September 2024
School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), Hainan University, Sanya 572025, China.
Article Synopsis
- - The study analyzed the wampee fruit (peel, pulp, and seed) from 17 different varieties using metabolomics, identifying a total of 1286 metabolites with health benefits, including lipids, flavonoids, polyphenols, and organic acids.
- - Significant variations in metabolite types and amounts were found among the fruit parts, with the peel having the most influence on the differences between varieties, leading to the identification of 7 potential biomarkers.
- - This research created a detailed overview of the wampee fruit's metabolome, providing valuable insights for isolating beneficial components, improving food industry uses, and enhancing nutritional breeding efforts.
Functionalized sodium alginate composite films based on double-encapsulated essential oil of wampee nanoparticles: a green preservation material.
Food Chem X
December 2024
School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of One Health, Hainan University, Haikou 570228, PR China.
Article Synopsis
- Researchers developed zein-pectin nanoparticles loaded with Wampee essential oil (WEO), which have a size of 515.9 nm and a zeta potential of -39.3 mV.
- These nanoparticles were then included in a sodium alginate-based film (ZWP-S) and analyzed for physical properties, thermal stability, and microstructure using various scientific techniques.
- The resulting ZWP-S film exhibited superior functional properties, such as increased tensile strength, enhanced antioxidant and antimicrobial activity, and effectively reduced the rotting rate of strawberries by 43% over six days, showing promise for extending the fruit's freshness.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!