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Bilateral Lesions in Parkinson's Disease: Gaps and Controversies.
Mov Disord
December 2024
Grenoble Alpes University, CHU of Grenoble, Division of Neurology, Grenoble Institute of Neurosciences, INSERM, Grenoble, France.
Bilateral lesions of the basal ganglia using termocoagulation or radiation for improving tremor, bradykinesia, and rigidity in people with Parkinson's disease (PD) have been performed starting several decades ago, especially when levodopa and deep brain stimulation (DBS) surgery were not available. However, because of unclear additional benefit compared to unilateral lesion, and particularly to the evidence of increased adverse events occurrence, bilateral lesions were basically abandoned at the end of the 20th century. Therefore, bilateral DBS has become the standard procedure to treat PD.
View Article and Find Full Text PDFWilms' Tumor - An Audit.
J Indian Assoc Pediatr Surg
November 2024
Department of Pathology, Lady Hardinge Medical College and Associated Kalawati Children's Hospital, New Delhi, India.
Background And Aims: Outcome analysis of patients with Wilms' tumors (WT) is presented.
Materials And Methods: A retrospective analysis of 23 children having WT managed by a single surgeon over 3 years (2021-2024) using the International Society of Paediatric Oncology Umbrella protocol was done.
Results: The median age at presentation was 36 months; 32 months and 24 months for the unilateral WT (uWT) ( = 19) and bilateral WT (bWT) ( = 4), respectively.
A Case Report of Mesenteric Panniculitis and Fibrous Dysplasia with Primary Metabolic Syndrome.
Eur J Case Rep Intern Med
November 2024
College of Medicine, University of Nebraska Medical Center, Omaha, USA.
Introduction: Mesenteric panniculitis (MP) is a rare clinically diagnosed disease resulting from fibro-inflammation in the intestinal adipose tissue. Precedent intra-abdominal inflammation or trauma is often evident. Fibrous dysplasia (FD) is a benign uncommon childhood disease of the bones, with fibrous connective tissue replacing bone tissue.
View Article and Find Full Text PDFOutcome of Retinoblastoma After Implementation of National Retinoblastoma Treatment Guidelines in South Africa.
JCO Glob Oncol
August 2024
Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Purpose: Retinoblastoma, a curable childhood cancer, has been identified as a tracer cancer in the WHO Global Initiative for Childhood Cancer. To document the outcomes of children with retinoblastoma in South Africa, treated as per the first prospective standard national treatment guidelines for childhood cancer in South Africa.
Patients And Methods: All children diagnosed with retinoblastoma between 2012 and 2016 in five South African pediatric oncology units were treated with a standard treatment on the basis of the International Society of Pediatric Oncology-Pediatric Oncology in Developing Countries guidelines for high-income settings.
Effectiveness of a Wilms tumour treatment guideline adapted to local circumstances in sub-Saharan Africa: A report from Wilms Africa Phase II-CANCaRe Africa.
Pediatr Blood Cancer
November 2024
CANCaRe Africa, The Collaborative African Network for Childhood Cancer Care and Research, Blantyre, Malawi.
Background: Wilms tumour (WT) is one of the cancer types targeted by the Global Initiative for Childhood Cancer (GICC). The objective of this study was to describe the outcomes of Wilms Africa Phase II in sub-Saharan Africa.
Methods: Wilms Africa Phase II used a comprehensive WT treatment protocol in a multi-centre, prospective study conducted in eight hospitals in Ethiopia (2), Ghana (2), Malawi, Cameroon, Zimbabwe and Uganda.
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