AI Article Synopsis
- The Ccr4-Not complex is a key deadenylase factor in eukaryotic cells, made up of at least seven subunits in mammals.
- It includes two main types of deadenylases: a DEDD-type (CNOT7/Caf1 or CNOT8) and an EEP-type (CNOT6/Ccr4 or CNOT6L).
- The text explores how the Ccr4-Not complex helps remove poly(A) tails from mRNA in the cytoplasm and the involvement of BTG/Tob proteins in this process.
Article Abstract
The Ccr4-Not complex is one of the major deadenylase factors present in eukaryotic cells. This multi-subunit protein complex is composed of at least seven stably associated subunits in mammalian cells including two enzymatic deadenylase subunits: one DEDD (Asp-Glu-Asp-Asp)-type deadenylase (either CNOT7/human Caf1/Caf1a or CNOT8/human Pop2/Caf1b/Calif) and one EEP (endonuclease-exonuclease-phosphatase)-type enzyme (either CNOT6/human Ccr4/Ccr4a or CNOT6L/human Ccr4-like/Ccr4b). Here, the role of the human Ccr4-Not complex in cytoplasmic deadenylation of mRNA is discussed, including the mechanism of its recruitment to mRNA and the role of the BTG/Tob proteins.
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| http://dx.doi.org/10.1042/BST20120074 | DOI Listing |
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