Topological indexes and QSRR methodology in pharmaceutical and chemical analysis.

This paper presents an assessment of the possibility of using topological indexes and related structural descriptors in TLC, HPLC, GC, micellar electrokinetic capillary chromatography (MEKC), and capillary zone electrophoresis (CZE) techniques. Every work quoted is a new aspect of the use of topological indexes. Data from the scientific literature indicate that the topological indexes discussed can be used to predict and describe retention and lipophilic parameters obtained by TLC, HPLC, GC, MEKC, and CZE for different classes of organic compounds including drugs. The results presented indicate that the topological indexes and other structural descriptors have significance in analytical investigations of organic compounds. This review indicates that further investigations on the application of the topological indexes in TLC, HPLC, GC, MEKC, and CZE are justifiable.