Purpose: Colonic elongation is reported as a possible cause for slow colonic transit, as it is observed in patients with slow-transit constipation (STC). This study aimed to determine the frequency of colonic elongation in children with STC or anorectal retention using radioimaging. We hypothesized that transverse colon elongation may occur in patients with STC, whereas sigmoid colon elongates in patients with anorectal retention.
Methods: Nuclear transit scintigraphy performed for chronic constipation (1999-2011) was analyzed qualitatively for elongated transverse colon or sigmoid colon. Three major colonic transit patterns were identified: slow transit in the proximal colon (STC), normal proximal colonic transit with anorectal retention (NT-AR), and rapid proximal transit ± anorectal retention (RT). χ(2) Test was used for statistical analysis (P < .05 significant).
Results: From 1999 to 2011, 626 children had nuclear transit scintigraphy. Transverse colon elongation occurred more frequently in STC (73/322, or 23%) compared with NT-AR (9/127, or 7%) and RT (5/177, or 3%; P < .0001). Sigmoid colon elongation was equally common in NT-AR (8/127, or 6%) compared with RT (10/177, or 6%) and STC (14/322, or 4%; P < .9).
Conclusion: Transverse colon elongation is more common in STC (23%), whereas sigmoid colon elongation is not more common in anorectal retention. Colonic elongation may be the cause or the result of the underlying slow colonic transit.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jpedsurg.2012.01.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Design and Analytical Modeling of a Dumbbell-Shaped Balloon Anchoring Actuator for Safe and Efficient Locomotion Inside Gastrointestinal Tract.
Soft Robot
December 2024
Multiscale Medical Robotics Centre Ltd., The Chinese University of Hong Kong, Shatin, Hong Kong.
Article Synopsis
- - Colorectal cancer is highly prevalent, accounting for nearly 10% of cancers and 9.2% of annual deaths, making improved detection methods critical.
- - Robotic "front-wheel" navigating colonoscopes provide a less painful alternative to traditional methods by reducing discomfort during examinations through enhanced anchoring technologies.
- - The study introduces a dumbbell-shaped balloon anchoring actuator (DBAA) that improves anchoring force while minimizing trauma to the colonic wall, with experimental results supporting its effectiveness compared to traditional techniques.
Sanguinarine chloride hydrate mitigates colitis symptoms in mice through the regulation of the intestinal microbiome and metabolism of short-chain fatty acids.
Biochim Biophys Acta Mol Basis Dis
February 2025
Technology Center of Kunming Customs, Kunming 650200, China. Electronic address:
Sanguinarine constitutes the main components of Macleaya cordata, and exhibits diverse biological and pharmacological activities. This study investigated the effects of sanguinarine chloride hydrate (SGCH) on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) mice. Five groups were designed to investigate the effects of SGCH on the pathological symptoms, the mRNA expression levels of inflammatory cytokines, colonic mucosal barrier damage, microbiota composition, and SCFAs metabolism in UC mice.
View Article and Find Full Text PDFDouble Twist and Shout: An Emergency Caused by Torsion of the Ovary and the Wandering Spleen.
Cureus
October 2024
Multidisciplinary Breast Clinic - Gynecologic Oncology, Antwerp University Hospital, Edegem, BEL.
Intermittent severe abdominal pain is a medical emergency with multiple possible underlying causes. This case report describes a 30-year-old female experiencing severe pelvic pain alternating between the left and right lower abdomen. The pain was periodic and very intense.
View Article and Find Full Text PDFRecurrence of Sigmoid Volvulus Associated With Constipation: A Retrospective Cohort Study.
Cureus
September 2024
Community Care, Unnan City Hospital, Unnan, JPN.
Article Synopsis
- Sigmoid volvulus is a condition where the sigmoid colon twists, causing obstruction and complications, often linked to factors like age, constipation, and medications.
- A study at Fuchu Hospital analyzed 44 patients and found that 20 had recurrences, with constipation identified as a major predictor of these recurrences.
- The findings suggest that managing constipation can help prevent future episodes, and further research is necessary to explore more preventive strategies with larger samples.
Curcumin Attenuates Dextran Sodium Sulfate Induced Colitis in Obese Mice.
Mol Nutr Food Res
October 2024
College of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi Province, 330004, China.
Scope: Curcumin (Cur), with diverse pharmacological properties, shows anti-obesity, immunomodulatory, and anti-inflammatory effects. Its role in ulcerative colitis complicated by obesity remains unclear.
Methods And Results: Here, colitis is induced in obese mice using dextran sulfate sodium (DSS), followed by administration of Cur at a dosage of 100 mg kg for 14 days.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!