AI Article Synopsis
- The study evaluates the effectiveness of aerosol-based delivery of azithromycin (AZM) for treating respiratory infections compared to oral administration.
- The aerosol formulation showed significantly higher therapeutic availability in alveolar macrophages (AMs) than the oral version, indicating better drug absorption.
- Results suggest that aerosolized AZM could be a promising method for targeting respiratory infections caused by pathogens in AMs.
Article Abstract
The efficacy of aerosol-based delivery of azithromycin (AZM) for the treatment of respiratory infections caused by pathogenic microorganisms infected in alveolar macrophages (AMs) was evaluated by comparison with oral administration. The aerosol formulation of AZM (0.2 mg/kg) was administered to rat lungs using a Liquid MicroSprayer(®). The oral formulation of AZM (50 mg/kg) was used for comparison. Time-courses of concentrations of AZM in AMs following administration were obtained, and then the therapeutic availability (TA) was calculated. In addition, the area under the concentrations of AZM in AMs - time curve/minimum inhibitory concentration at which 90% of isolates ratio (AUC/MIC90) were calculated to estimate the antibacterial effects in AMs. The TA of AZM in AMs following administration of aerosol formulation was markedly greater than that following administration of oral formulation. In addition, the AUC/MIC90 of AZM in AMs was markedly higher than the effective values. This indicates that the aerosol formulation could be useful for the treatment of respiratory infections caused by pathogenic microorganisms infected in AMs. This study suggests that aerosolized AZM is an effective pulmonary drug delivery system for the treatment of respiratory infections.
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| http://dx.doi.org/10.3109/10837450.2012.705296 | DOI Listing |
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