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Cytomegalovirus Infections in Hematopoietic Stem Cell Transplant: Moving Beyond Molecular Diagnostics to Immunodiagnostics.
Diagnostics (Basel)
November 2024
College of Nursing and Health Sciences, Jazan University, Jazan 45142, Saudi Arabia.
Human CMV, regularly reactivated by simple triggers, results in asymptomatic viral shedding, powerful cellular immune responses, and memory inflation. Immunocompetent individuals benefit from a robust immune response, which aids in viral management without causing clinically significant illness; however, immunodeficient individuals are always at a higher risk of CMV reactivation and disease. Hematopoietic stem cell transplant (HSCT) recipients are consistently at higher risk of CMV reactivation and clinically significant CMV illness due to primary disease, immunosuppression, and graft vs.
View Article and Find Full Text PDFHCMV strain- and cell type-specific alterations in membrane contact sites point to the convergent regulation of organelle remodeling.
J Virol
November 2024
Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Viruses are ubiquitous entities that infect organisms across the kingdoms of life. While viruses can infect a range of cells, tissues, and organisms, this aspect is often not explored in cell culture analyses. There is limited information about which infection-induced changes are shared or distinct in different cellular environments.
View Article and Find Full Text PDFCyclin-Dependent Kinase 8 Represents a Positive Regulator of Cytomegalovirus Replication and a Novel Host Target for Antiviral Strategies.
Pharmaceutics
September 2024
Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Schlossgarten 4, 91054 Erlangen, Germany.
Article Synopsis
- Cyclin-dependent kinase 8 (CDK8) helps control how viruses, especially the human cytomegalovirus (HCMV), grow in our cells by affecting important processes in their life cycles.
- Scientists tested some drugs that stop CDK8 to see if they could help fight HCMV, and they found that these drugs made the virus grow much less in cell cultures.
- The research showed that CDK8 is crucial for HCMV's later stages of growth, and using CDK8 inhibitors together with other treatments could work really well against the virus.
Infection-induced peripheral mitochondria fission drives ER encapsulations and inter-mitochondria contacts that rescue bioenergetics.
Nat Commun
August 2024
Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
The dynamic regulation of mitochondria shape via fission and fusion is critical for cellular responses to stimuli. In homeostatic cells, two modes of mitochondrial fission, midzone and peripheral, provide a decision fork between either proliferation or clearance of mitochondria. However, the relationship between specific mitochondria shapes and functions remains unclear in many biological contexts.
View Article and Find Full Text PDFCytomegalovirus infection in non-immunocompromised critically ill patients: A management perspective.
World J Virol
March 2024
Institute of Critical Care Medicine, Max Super Speciality Hospital, Saket, New Delhi 110017, India.
Critically ill patients are a vulnerable group at high risk of developing secondary infections. High disease severity, prolonged intensive care unit (ICU) stay, sepsis, and multiple drugs with immunosuppressive activity make these patients prone to immuneparesis and increase the risk of various opportunistic infections, including cytomegalovirus (CMV). CMV seroconversion has been reported in up to 33% of ICU patients, but its impact on patient outcomes remains a matter of debate.
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