From a statutory standpoint, the decision-making capacity of adolescents differs significantly from that of adults because adolescents are considered to lack the experience and judgment necessary to make legally binding decisions. Furthermore, in the case of minors, the principle of protection of life tends to outweigh the principle of autonomy. Here we present the hypothetical case of a 16-year-old boy with spinalmuscular atrophy type II who was admitted to the intensive care unit for severe respiratory distress. We focus on the tension that developed among the patient, his parents, and his physicians when the need for emergency mechanical ventilation became apparent. We review the legal and ethical premises under which adolescents are permitted to make legally binding decisions, ie, the emancipated minor and the mature minor doctrines. Finally, we discuss the concepts of protectionism and liberationism as they apply to adolescents' decision-making capacity.
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http://dx.doi.org/10.1212/01.CON.0000394681.97867.b3 | DOI Listing |
Sports Med
December 2024
Ultra Sports Science Foundation, Pierre-Bénite, France.
Background: Antarctic expeditions, although supported by scientific knowledge, face various challenges, with little research conducted to explore the physical demands that explorers experience.
Objective: To summarise physiological, psychological, body composition and nutritional changes faced during trek expeditions in the Antarctic's continental portion.
Design: Systematic review.
BMC Health Serv Res
December 2024
National Commission on Certification of Physician Assistants, 12000 Findley Road, Suite 200, Johns Creek, Georgia, 30097, USA.
Background: Physician assistants/associates (PAs), due to their broad medical education and certification, have the flexibility to change specialties throughout their careers. Prior studies suggest that between half and three-quarters exercise this option at some point in their career, and a third do so within the first decade. However, more research is needed to understand the factors associated with PAs changing vs.
View Article and Find Full Text PDFSci Rep
December 2024
School of Management, Shenyang University of Technology, Shenyang, 100870, China.
This study presents a novel framework for advancing sustainable urban logistics and distribution systems, with a pivotal focus on fast charging and power exchange modalities as the cornerstone of our research endeavors. Our central contribution encompasses the formulation of an innovative electric vehicle path optimization model, whose paramount objective is to minimize overall operational costs. Integrating V2G technology, we facilitate sophisticated slow charging and discharging management of EVs upon their return to distribution centers, enhancing resource utilization.
View Article and Find Full Text PDFMetabolites
December 2024
Developmental Biology Department, Institute of Biology Bucharest of Romanian Academy, 296 Splaiul Independentei, 060031 Bucharest, Romania.
This research article delves into Babaco fruit's-an Ecuadorian product with immense nutraceutical potential phytochemical composition and biological activity-in different maturation fruit stages. Bridging the gap between food and medicine, nutraceuticals offer health benefits beyond basic nutrition. Specifically, this study investigates Babaco's antioxidant and its phenolic and flavonoid content across different ripening stages: physiological maturity, organoleptic quality immaturity, and commercial maturity.
View Article and Find Full Text PDFAdv Mater
December 2024
Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Department of Chemistry, Fudan University, Shanghai, 200032, China.
While tumor organoids have revolutionized cancer research by recapitulating the cellular architecture and behaviors of real tumors in vitro, their lack of functional vasculature hinders their attainment of full physiological capabilities. Current efforts to vascularize organoids are struggling to achieve well-defined vascular networks, mimicking the intricate hierarchy observed in vivo, which restricts the physiological relevance particularly for studying tumor progression and response to therapies targeting the tumor vasculature. An innovative vascularized patient-derived tumor organoids (PDTOs)-on-a-chip with hierarchical, tumor-specific microvasculature is presented, providing a versatile platform to explore tumor-vascular dynamics and antivascular drug efficacy.
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