Studies on the heredity of dental characteristics in humans have indicated that the variance in many dental traits results from genetic variation. However, the genetic factors that influence commonly occurring dental variants are poorly understood. Paired domain box 9 (PAX9) codes a transcription factor that is important in tooth development. We investigated whether PAX9 polymorphisms are associated with normal variations in tooth agenesis and morphology. The study subjects were 273 Japanese and 223 Korean adults. Single-nucleotide polymorphisms (SNPs) in PAX9 (rs2295222, rs4904155, rs2073244, rs12881240 and rs4904210) were genotyped, and third molar agenesis and mesiodistal and buccolingual diameters were measured. We found that four of the five SNPs were significantly associated with the crown size. However, no SNP was associated with third molar agenesis. In additional analyses on non-metric dental traits, we found significant associations of PAX9 SNPs with shoveling of upper first incisors. In summary, common variants in PAX9 contributed to morphological variation in permanent teeth in humans.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/jhg.2012.90 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Anxiety, mental suffering, and bruxism in dental students in the COVID-19 postpandemic moment.
J Dent Educ
January 2025
Dental School, Community University of the Chapecó Region - Unochapecó, Chapecó, Santa Catarina, Brazil.
Objectives: The COVID-19 pandemic was devastating, causing deaths, economic and social problems, and mental disorders in the lives of many people. After 3 years, the mental repercussions caused by the pandemic are unclear, especially in young adults. This study assessed the occurrence of mental disorders, anxiety, and bruxism in dental students during the postpandemic moment and determined the factors that influenced the occurrence of bruxism.
View Article and Find Full Text PDFConvergent Isobilateral Leaves Increase the Risk for Mangroves Facing Human-Induced Rapid Environmental Changes.
Plant Cell Environ
January 2025
Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, College of the Environment and Ecology, Xiamen University, Xiamen, China.
Understanding plant adaptations in extreme environments is crucial, as these adaptations often confer advantages for survival. However, a significant gap exists regarding the genetic mechanisms underlying these adaptations and their responses to human-induced rapid environmental change (HIREC). This study addresses the question of whether genetic convergence occurs among plants with similar adaptive features, specifically focusing on isobilateral leaves in mangrove species.
View Article and Find Full Text PDFStudy the effect of ATCC 14917 for caries prevention and anti-obesity.
Front Nutr
December 2024
Department of Pedodontics, Affiliated Stomatology Hospital of Jinzhou Medical University, Jinzhou, China.
Introduction: A complicated scenario where "multiple disease threats coexist and multiple health influencing factors are intertwined" is demonstrated by the fact that dental caries, obesity myopia and scoliosis have emerged as global public health issues. The problem of diseases co-existing in living things can be resolved by using probiotics. , has gained attention recently due to its probiotic properties, useful traits, and potential medical applications.
View Article and Find Full Text PDFCleft palate, congenital heart disease, and developmental delay involving heterozygous mutations found in the patient with attention deficit hyperactivity disorder: a case report.
Front Pediatr
December 2024
Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education (MOE), Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
This case is the first reported patient with a gene mutation who primarily exhibits pronounced inattention as the main manifestation and is diagnosed with ADHD, requiring methylphenidate treatment. It is characterized by unique clinical features that set it apart from previously reported cases with mutations in the gene. Here, we report a female child with a diagnosis of ADHD and comorbidities.
View Article and Find Full Text PDFExploring oral health challenges and integration strategies in opioid treatment programs: perspectives from clinicians and clients.
Aust J Prim Health
January 2025
Drug and Alcohol Services, Northern Sydney Local Health District, NSW Health, St Leonards, NSW, Australia; and Specialty of Addiction Medicine, Northern Clinical School, The University of Sydney, St Leonards, NSW, Australia; and National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, Australia.
Background Despite the paramount importance of oral health, individuals undergoing treatment for opioid use disorder face unique challenges beyond traditional addiction care. This qualitative study explores the challenges Opioid Treatment Program (OTP) clients in Australia encounter when accessing oral health care, aiming to understand the underlying factors and identify effective strategies for integrating oral health into an OTP. Methods Semi-structured interviews were conducted with OTP clients, OTP clinicians and oral health clinicians using tested interview guides.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!