AI Article Synopsis
- A rare case of an immunocompetent patient developed an infection from Candida albicans in an artificial hip joint, which resisted standard treatments.
- The initial treatment involved removing part of the femur and using gentamicin-coated cement beads, followed by a second procedure with a custom cement spacer coated in antifungals and antibiotics.
- Six years later, the patient is healthy with a minor limp and no signs of reinfection, marking a significant finding in the effective release of antifungal medications from bone cement.
Article Abstract
We present a rare case of an immunocompetent host who developed a Candida albicans-infected total hip prosthesis. The infection could not be eradicated with debridement and extensive antifungal therapy. Our patient first underwent a resection of the proximal femur and local treatment with gentamicin-loaded cement beads. In a second procedure, a handmade cement spacer impregnated with voriconazole, amphotericin B, and vancomycin was placed. After 3 months of additional systemic antibiotic therapy, the patient remained afebrile, and a tumor prosthesis was placed. Six years postoperatively, she is doing well, walking with a small limp and no signs of recurrent infection. This is the first report on elution of voriconazole and amphotericin B from bone cement delivered at clinically significant concentrations for at least 72 hours.
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| http://dx.doi.org/10.1016/j.arth.2012.04.034 | DOI Listing |
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