AI Article Synopsis
- Th22 cells are involved in human cancers, specifically in the context of malignant pleural effusion (MPE), but their differentiation and immune function in this scenario are not fully understood.
- Researchers found that Th22 cell numbers were higher in MPE and that IL-22, a cytokine, significantly enhanced the growth and movement of A549 cancer cells.
- The increase in Th22 cells in MPE is linked to certain cytokines and chemokines present in the pleural environment, suggesting that Th22 plays a crucial role in immune regulation of cancer cells in this context.
Article Abstract
Th22 cells have been reported to be involved in human cancers. However, differentiation and immune regulation of Th22 cells in malignant pleural effusion (MPE) remain unknown. We noted that Th22 cell numbers were increased in MPE, and that IL-22 substantially promoted the proliferation and migratory activity of A549 cells. Moreover, IL-22 could strongly facilitate intercellular adhesion of A549 cells to pleural mesothelial cell monolayers. Our data revealed that the increase in Th22 cells in MPE was due to pleural cytokines and chemokines, and that Th22 exerted an important immune regulation on cancer cells in human pleural malignant environment.
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| http://dx.doi.org/10.1016/j.canlet.2012.07.013 | DOI Listing |
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