Experimental studies of photostimulation of the visual analyzer by combinations of red, green, blue, and yellow colors in a pulsed mode were carried out. Significant improvement of a visual acuity is shown after photostimulation course in patients with macular degeneration and degenerative changes of the optic nerve.
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http://dx.doi.org/10.1007/s10517-011-1497-3 | DOI Listing |
bioRxiv
December 2024
Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Spiking activity along synaptic circuits linking primary somatosensory (S1) and motor (M1) areas is fundamental for sensorimotor integration in cortex. Circuits along the ascending somatosensory pathway through mouse hand/forelimb S1 and M1 were recently described in detail (Yamawaki et al., 2021).
View Article and Find Full Text PDFInt J Retina Vitreous
September 2024
Division of Ophthalmology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
bioRxiv
August 2024
Department of Neuroscience, University of California, Berkeley.
Observation of neural firing patterns can constrain theories for the types of activity patterns that the brain uses to guide behavior. However, directly perturbing these patterns, ideally with great specificity, is required to causally test any particular theory. We combined two-photon imaging and cellular resolution optogenetic photo-stimulation to causally test how neural activity in the mouse visual cortex is read out to detect visual stimuli.
View Article and Find Full Text PDFbioRxiv
August 2024
Cell Biology and Neuroscience Department, Rutgers University, The State University of New Jersey, New Brunswick, NJ, United States of America.
Background: Closed-loop behavior paradigms enable us to dissect the state-dependent neural circuits underlying behavior in real-time. However, studying context-dependent locomotor perturbations has been challenging due to limitations in molecular tools and techniques for real-time manipulation of spinal cord circuits.
New Method: We developed a novel closed-loop optogenetic stimulation paradigm that utilizes DeepLabCut-Live pose estimation to manipulate primary sensory afferent activity at specific phases of the locomotor cycle in mice.
Neurophotonics
July 2024
University of Michigan, Department of Biomedical Engineering, Ann Arbor, Michigan, United States.
Significance: Many techniques exist for screening retinal phenotypes in mouse models in vision research, but significant challenges remain for efficiently probing higher visual centers of the brain. Photoacoustic computed tomography (PACT), with optical sensitivity to hemodynamic response (HR) in brain and ultrasound resolution, provides unique advantages in comprehensively assessing higher visual function in the mouse brain.
Aim: We aim to examine the reliability of PACT in the functional phenotyping of mouse models for vision research.
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