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A model of hyperhomocysteine-induced endothelial dysfunction in rats. | LitMetric
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A model of hyperhomocysteine-induced endothelial dysfunction in rats.

M V Korokin M V Pokrovskiy O O Novikov O S Gudyrev V V Gureev T A Denisyuk L V Korokina L M Danilenko V A Ragulina E A Konovalova A S Belous

Bull Exp Biol Med

Kursk State Medical University, Ministry of Health Care and Social Development of the Russian Federation, Russia.

Published: December 2011

Intragastric methionine (3 g/kg daily for 7 days) elevates homocysteine concentration and increases the endothelial dysfunction coefficient. This protocol of methionine treatment is an adequate model of hyperhomocysteine-induced endothelial dysfunction and can be used for studies of the endothelio- and cardioprotective effects of drugs.

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 Source
http://dx.doi.org/10.1007/s10517-011-1491-9DOI Listing

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