Secretory activity of the adrenal cortex and hormonal reaction to emotional stress were examined in normotensive WAG and hypertensive ISIAH rats. Under nembutal narcosis (surgical stage), secretion of corticosteroid hormones and hormonal reaction to acute stress in hypertensive rats were enhanced. In these rats, the stress-induced elevation of aldosterone secretion was most pronounced, which indicates an important contribution of this hormone to the pathogenesis of stress-dependent arterial hypertension.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-011-1484-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Acid sphingomyelinase inhibition induces cerebral angiogenesis post-ischemia/reperfusion in an oxidative stress-dependent way and promotes endothelial survival by regulating mitochondrial metabolism.
Cell Death Dis
September 2024
Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Article Synopsis
- Acid sphingomyelinase (ASM) inhibitors, like amitriptyline, aid in recovering from post-stroke depression and enhance neurological recovery through neurorestorative effects in stroke models.
- The study revealed that amitriptyline boosts the formation of mitochondrial reactive oxygen species (ROS) in both human endothelial cells and mice models, which plays a key role in its ability to promote angiogenesis.
- Furthermore, amitriptyline triggers a metabolic reprogramming in endothelial cells that reduces harmful stress while encouraging protective responses, with the antioxidant heme oxygenase-1 being crucial for mediating its angiogenic effects.
Effect of Short-Term Restraint Stress on the Hypothalamic Transcriptome Profiles of Rats with Inherited Stress-Induced Arterial Hypertension (ISIAH) and Normotensive Wistar Albino Glaxo (WAG) Rats.
Int J Mol Sci
June 2024
Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Emotional stress is one of the health risk factors in the modern human lifestyle. Stress exposure can provoke the manifestation of various pathological conditions, one of which is a sharp increase in the blood pressure level. In the present study, we analyzed changes in the transcriptome profiles of the hypothalamus of hypertensive ISIAH and normotensive WAG rats exposed to a single short-term restraint stress (the rat was placed in a tight wire-mesh cage for 2 h).
View Article and Find Full Text PDFSodium-glucose cotransporter 2 inhibitors attenuate vascular calcification by suppressing endoplasmic reticulum protein thioredoxin domain containing 5 dependent osteogenic reprogramming.
Redox Biol
July 2024
Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China. Electronic address:
Aims: Vascular calcification is strongly linked to the development of major adverse cardiovascular events, but effective treatments are lacking. Sodium-glucose cotransporter 2 (SGLT2) inhibitors are an emerging category of oral hypoglycemic drugs that have displayed marked effects on metabolic and cardiovascular diseases, including recently reported vascular medial calcification. However, the roles and underlying mechanisms of SGLT2 inhibitors in vascular calcification have not been fully elucidated.
View Article and Find Full Text PDFvon Willebrand factor Ristocetin co-factor activity to von Willebrand factor antigen level ratio for diagnosis of acquired von Willebrand syndrome caused by aortic stenosis.
Res Pract Thromb Haemost
January 2024
Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University Graduate School of Medicine, Sendai, Japan.
Article Synopsis
- Severe aortic stenosis (AS) can lead to acquired von Willebrand syndrome by breaking down important blood clotting factors, requiring accurate diagnosis methods to identify the condition.* -
- The study evaluated the effectiveness of the VWF Ristocetin co-factor activity to antigen levels (VWF:RCo/VWF:Ag) ratio as a diagnostic tool for AS-induced von Willebrand syndrome using data from 382 AS patients and controls.* -
- Results showed a VWF:RCo/VWF:Ag ratio of <0.7 is specific for detecting loss of important blood clotting multimers in patients with AS, but it has low sensitivity, indicating it might miss some cases.*
ALKBH5 protects against stroke by reducing endoplasmic reticulum stress-dependent inflammation injury via the STAT5/PERK/EIF2α/CHOP signaling pathway in an mA-YTHDF1-dependent manner.
Exp Neurol
February 2024
Department of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, PR China. Electronic address:
Background: Endoplasmic reticulum (ER) stress causes neuroinflammation and neuronal apoptosis during ischemic stroke progression. This study has investigated the role of ALKBH5 in ER stress during ischemic stroke progression.
Methods: In vivo and in vitro models of ischemic stroke were established by middle cerebral artery occlusion (MCAO) and OGD/R treatment, respectively.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!