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Levofloxacin-Induced Hepatotoxicity in Patients With Legionnaires' Disease: Implications and Management.
Cureus
December 2023
Gastroenterology and Hepatology, Rutgers University New Jersey Medical School, Newark, USA.
Legionnaires' disease (LD), caused by the bacterium, primarily manifests as pneumonia and could result in a spectrum of clinical severity. As treatment necessitates the use of antibiotics, levofloxacin, a fluoroquinolone, is a commonly preferred option due to its broad-spectrum activity. However, the potential side effects of levofloxacin, including rare instances of hepatotoxicity, introduce a therapeutic challenge.
View Article and Find Full Text PDFA Rare Case of Levofloxacin-Induced Acute Pancreatitis: Case Report and Literature Review.
Cureus
July 2023
Family Medicine, Brightstar Care, Sugarland, USA.
Article Synopsis
- Diagnosing drug-induced acute pancreatitis is often missed, as it's a rare condition that requires ruling out other common causes like alcohol and gallstones.
- Levofloxacin, an antibiotic used for bacterial infections, can occasionally lead to acute pancreatitis, despite its more common side effects.
- A case study highlights a woman who developed acute pancreatitis after taking levofloxacin for a urinary tract infection, with diagnosis confirmed through clinical and laboratory evaluations.
Levofloxacin-induced severe cutaneous adverse drug reactions (LEV-SCARs) remain unexplored. An association study of human leukocyte antigen () alleles with LEV-SCARs among 12 patients, 806 healthy subjects, and 100 levofloxacin-tolerant individuals was performed. The carrier frequencies of (odds ratio [OR]: 4.
View Article and Find Full Text PDFLevofloxacin-Induced Toxic Epidermal Necrolysis.
Cureus
May 2023
International Medical, Avalon University School of Medicine, Youngstown, USA.
Toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, is a severe episodic mucocutaneous reaction that is usually brought on by oral medications and/or sporadically by infections. We report a case of a 19-year-old male with the presenting complaint of generalized skin blistering over the previous seven days at the dermatology outpatient clinic. The patient has had epilepsy since he was 10 years old.
View Article and Find Full Text PDFRetrospective analysis of risk factors for levofloxacin-induced liver injury.
J Chemother
December 2023
Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan.
Levofloxacin is used as a first-line drug for the treatment of pneumonia. However, the relatively high incidence of drug-induced liver injury (DILI) remains a clinical problem. Based on the available patient data, this study aimed to identify the risk factors for DILI before levofloxacin administration.
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