CD40 ligation has been shown to induce antitumor effects in mice and cancer patients. Most of the studies have focused on the ability of an agonistic anti-CD40 mAb to either directly kill CD40-positive tumor cells or activate T-cell immune responses. In this review the authors focus on the ability of CD40 ligation to activate antitumor effector mechanisms of the cells of innate immunity such as macrophages and NK cells.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537496 | PMC |
| http://dx.doi.org/10.3109/08830185.2012.698337 | DOI Listing |
Publication Analysis
Top Keywords
cd40 ligation
12
antitumor effects
8
t-cell-independent antitumor
4
effects cd40
4
ligation cd40
4
ligation induce
4
induce antitumor
4
effects mice
4
mice cancer
4
cancer patients
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!