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Dimebon reduces the levels of aggregated amyloidogenic protein forms in detergent-insoluble fractions in vivo. | LitMetric
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Dimebon reduces the levels of aggregated amyloidogenic protein forms in detergent-insoluble fractions in vivo.

A A Ustyugov T A Shelkovnikova V S Kokhan I V Khritankova O Peters V L Buchman S O Bachurin N N Ninkina

Bull Exp Biol Med

Department of Medical and Biological Chemistry, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Russia.

Published: April 2012

Aggregation of proteins liable to assembling into fibrils with subsequent formation of amyloid incorporations is an important component in the pathogenesis of many neurodegenerative diseases. Dimebon, a Russian drug, reduces the content of detergent-insoluble fibrillar forms of synuclein, the main protein component of pathological incorporations in neurons of transgenic mouse strain used in the study.

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http://dx.doi.org/10.1007/s10517-012-1618-7DOI Listing

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