Background: The purpose of this study was to evaluate ADC values in the preoperative grading of primary infratentorial brain tumors in children. MATERIAL /METHODS: We retrospectively reviewed 50 MR examinations of patients with infratentorial tumors. All children were operated on and tumors were histopathologically proved as low-grade - 25 (24 pilocytic astrocytomas, 1 ependymoma) and high-grade lesions - 25 (19 medulloblastomas, 6 anaplastic ependymomas). In all patients with contrast-enhanced tumors, ROIs were placed in the enhanced region. In patients with non-enhancing tumors, ROIs were placed in the solid part of the lesion. Cystic, hemorrhagic and necrotic areas of tumors were excluded. Statistical analysis was performed by using a Student's t-test.
Results: Statistically significant differences were found in the comparisons of mean ADC of pilocytic astrocytomas (1.54×10(-3)mm(2)/s ±0.2) with medulloblastomas (0.75×10(-3)mm(2)/s ±0.075) and pilocytic astrocytomas (1.54×10(-3)mm(2)/s ±0.2) with anaplastic ependymomas (0.99×10(-3)mm(2)/s ±0.25). Statistical analysis including ependymomas should be discussed, because of small number of these tumors and a non-homogenous group of lesions.
Conclusions: DWI imaging and ADC map provide useful information for preoperative grading of infratentorial tumors in children.
Background: Neuroblastoma is the most prevalent extracranial solid tumor in pediatric populations worldwide, representing 8-10% of childhood malignancies and contributing to approximately 15% of pediatric cancer-related fatalities. This study aims to report global trends in the incidence, mortality, and disability-adjusted life years (DALYs) of childhood neuroblastoma from 1990 to 2021.
Methods: The study utilized data from the Global Burden of Disease (GBD) database to analyze neuroblastoma incidence, mortality, and DALYs in children aged 0-14 years.
Objectives: Limping is a frequent reason for visits to emergency departments. The causes of limping in children are various, ranging from benign musculoskeletal problems to serious etiologies, such as malignancy and infections.
Methods: In this recent cross-sectional study, we evaluated the causes of limps in children referred to the pediatric rheumatology ward in northeast Iran.
A rare case of a pure yolk sac testicular tumour presenting in an adult with learning difficulties is presented. Pure yolk sac tumours are much more common in children, but when they do occur in adults, onset can be both insidious and aggressive. The best practice for identification involves the precise use of ultrasound, blood tests for tumour markers and FDG-PET/CT imaging for staging.
Introduction: This study aimed to investigate the clinical significance and potential mechanism of long non-coding RNA human histocompatibility leukocyte antigen complex P5 (HCP5) in neonatal sepsis (NS).
Material And Methods: The study enrolled 86 patients with NS and 80 neonates with respiratory tract infection or pneumonia. The Pearson correlation coefficient was used to evaluate the association of procalcitonin (PCT), C-reactive protein (CRP), and inflammatory factors with HCP5.
