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Comparative analysis of the structure and content of N-glycans from different commercial whey protein materials.
J Food Sci
January 2025
College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin, China.
Infant formulas are constantly being updated and upgraded, and N-glycans are functional glycans that have not been fully exploited to date. Commercial whey protein materials are often used as basic ingredients in infant formulas. Therefore, it is important to study N-glycans in commercial whey protein materials.
View Article and Find Full Text PDFA nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by C-type lectin pathway-mediated tumor associated macrophages repolarizing.
Int J Biol Macromol
January 2025
Department of Medical Microbiology, Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences, Fudan University, Shanghai, China; Translational Glycomics Research Center, Fudan Zhangjiang Institute, Shanghai, China. Electronic address:
Aberrant sialylated glycosylation in the tumor microenvironment is a novel immune suppression pathway, which has garnered significant attention as a targetable glycoimmune checkpoint for cancer immunotherapy to address the dilemma of existing therapies. However, rational drug design and in-depth mechanistic studies are urgently required for tumor sialic acid to become valuable glycoimmune targets. In this study, we explored the positive correlation of PD-L1 and sialyltransferase expression in clinical colorectal cancer tissues and identified their mutual regulation effects in macrophages.
View Article and Find Full Text PDFLC-MS/MS-Based Site-Specific N-Glycosylation Analysis of VEGFR-IgG Fusion Protein for Sialylation Assessment Across IEF Fractions.
Molecules
November 2024
Department of Biomedical Science, Cheongju University, Cheongju 28160, Republic of Korea.
Article Synopsis
- - The glycosylation profile of therapeutic proteins, especially sialylation, is important for their effectiveness and stability, particularly in fusion proteins used to treat angiogenic disorders.
- - A mass spectrometry method was used to analyze sialylation levels in VEGFR-IgG fusion proteins by examining different fractions from production media, revealing varying sialylation levels.
- - The study found that the overall sialylation levels matched the expected results from the different fractions, emphasizing the importance of LC-MS/MS-based analysis for quality control and consistency in biosimilar development.
Local and Noninvasive Glyco-Virus Checkpoint Nanoblockades Restrict Sialylation for Prolonged Broad-Spectrum Epidemic Virus Therapy.
ACS Nano
November 2024
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, and Chemical Biology Center, Peking University, Beijing 100191, China.
The coronavirus disease 2019 (COVID-19) pandemic has driven major advances in virus research. The role of glycans in viral infection has been revealed, with research demonstrating that terminal sialic acids are key receptors during viral attachment and infection into host cells. However, there is an urgent demand for universal tools to study the mechanism of sialic acids in viral infections, as well as to develop therapeutic agents against epidemic viruses through the downregulation of terminal sialic acid residues on glycans acting as a glyco-virus checkpoint to accelerate virus clearance.
View Article and Find Full Text PDFA dual-capture-system polymer based on imprinted cavities and post-imprinting modification sites with significantly improved affinity and specificity for sialic acid and sialylated glycoprotein.
Int J Biol Macromol
December 2024
Tang Center for Herbal Medicine Research and Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL 60637, USA.
Article Synopsis
- The study discusses the challenges in detecting N-acetylneuraminic acid (SA) and sialylated glycoproteins in biological samples, which are linked to diseases like cancer.
- A dual-capture system using molecular imprinting and post-imprinting modifications (PIM) was developed to enhance the binding efficiency and specificity of SA capture.
- The new magnetic polymers (Mag-MIPs-PIM) showed high specificity for both SA and sialylated glycoproteins, achieving a low detection limit and proving effective in human serum analysis.
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