AI Article Synopsis
- - The study examined the differences in serum proteins among 144 patients with esophageal squamous cell carcinoma and 50 healthy volunteers using advanced mass spectrometry techniques.
- - Out of 93 detected protein peaks, 10 showed significant differences, with notable findings in stages II and III of the cancer concerning patient survival time.
- - The findings suggest that specific serum proteins can provide insights into the prognosis of esophageal squamous cell carcinoma, potentially aiding in clinical diagnosis and treatment.
Article Abstract
Objective: To assess differences in serum proteins in esophageal squamous cell carcinoma patients.
Methods: 144 esophageal squamous cell carcinoma patients and 50 healthy volunteers were included in this study, with surface-enhanced laser desorption-ionization time-of-flight mass spectrometry and weak cation exchange magnetic beads. Follow-up allowed the relations between serum proteins and prognosis to be analyzed.
Results: A total of 93 protein peaks were detected (molecular weight range: 1500-3000), 10 demonstrating statistically significant differences. There were no differences in protein peaks between 92 patients with a survival more than 2 years and 52 patients with survival less than 2 years. There were two significantly different protein peaks between 45 stage II patients with a survival more than 2 years and 14 stage II patients with survival less than 2 years. There was one significantly different protein peak between 22 stage III patients with a survival more than 2 years and 29 stage III patients with survival less than 2 years.
Conclusion: Differences of serum proteins in esophageal squamous cell carcinoma are related to prognosis of patients. The protein fingerprint can be helpful for clinical diagnosis and treatment.
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| http://dx.doi.org/10.7314/apjcp.2012.13.4.1579 | DOI Listing |
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