AI Article Synopsis
- The study aimed to examine the link between specific gene polymorphisms (GSTM, GSTT, GSTP) and survival rates in gastric cancer patients in China.
- A total of 317 gastric cancer patients were followed for an average of 34.2 months, with 120 deaths recorded during the study.
- Results indicated that individuals with the GSTT1-null genotype had a significantly higher risk of death, and those with both null-GSTM1 and null-GSTT1 genotypes also showed increased mortality risk from gastric cancer.
Article Abstract
Aim: We conducted a prospective study in an Chinese population to detect the association between GSTM, GSTT and GSTP gene polymorphisms and survival of gastric cancer.
Methods: A prospective follow-up study with 317 gastric cancer patients was conducted between January 2003 and January 2005. GSTM1, GSTT1 and GSTP1 genotyping was performed using ABI TaqMan Gene Expression assays.
Results: Of 317 patients, 5 were lost to follow-up due to migration, while the remaining 302 patients completed the study. The median follow-up time was 34.2 months (range: 2 to 60 months), during which a total of 120 (39.1%) died of gastric cancer. The GSTT1-null genotype showed a significant increased risk of death from gastric cancer, with an HR (95% CI) of 1.59 (1.04-3.58). Moreover, we found individuals carrying null-GSTM1 and null-GSTT1 had a moderate higher risk of death from gastric cancer, with an HR of 1.92 (1.05-3.65).
Conclusion: This study reported the carriage of null GSTT1 and null GSTM1 might be linked to the higher death risk from gastric cancer in Chinese population.
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| http://dx.doi.org/10.7314/apjcp.2012.13.4.1515 | DOI Listing |
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