AI Article Synopsis
- The text discusses the increasing understanding of porcine respiratory and reproductive syndrome virus (PRRSV) proteins, while emphasizing the lesser-known role of host factors in modifying infections.
- It highlights the importance of deubiquitination in various regulatory processes, including immune responses and disease conditions like cancer and infections.
- The report presents findings that overexpression of porcine ubiquitin-specific peptidase 18 (USP18) in MARC-145 cells can limit PRRSV growth by activating the NF-κB pathway, positioning USP18 as a crucial host restriction factor in fighting PRRSV infections.
Article Abstract
Although the functions of porcine respiratory and reproductive syndrome virus (PRRSV) proteins are increasingly understood, the roles of host factors in modifying infection are less well understood. Growing evidence places deubiquitination at the core of a multitude of regulatory processes, ranging from cell growth to innate immune response and health, such as cancer, degenerative and infectious diseases. This report provides further information on the functional role of the porcine ubiquitin-specific peptidase 18 (USP18) during innate immune responses to PRRSV. We have shown that constitutive overexpression of the porcine USP18 in MARC-145 cells restricts PRRSV growth, at least in part via early activation of NF-κB. Viral growth of PRRSV may be perturbed by increasing and decreasing nuclear translocation of p65 and p50, respectively. Our data highlight USP18 as a host restriction factor during innate immune response to PRRSV.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501733 | PMC |
| http://dx.doi.org/10.1016/j.virusres.2012.07.002 | DOI Listing |
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