Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.numecd.2012.05.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genetic Polymorphisms and Genetic Risk Scores Contribute to the Risk of Coronary Artery Disease (CAD) in a North Indian Population.
Int J Mol Sci
August 2024
Department of Human Genetics, Punjabi University, Patiala 147002, India.
Article Synopsis
- - Coronary artery disease (CAD) is a major health issue in India, and this study looked at ten genetic polymorphisms affecting oxidative stress, blood pressure, and lipid metabolism in the Jat Sikh population to understand their link to CAD risk.
- - The research found that seven of these polymorphisms, specifically M235T, T174M, and A1166C, showed significant associations with increased CAD risk, with some haplotypes linked to higher risk even when accounting for other factors.
- - A higher polygenic risk score indicated a nearly double risk of developing CAD, highlighting important genetic factors for potential clinical and public health strategies in preventing and managing coronary artery disease.
Investigation of associations between apolipoprotein A5 and C3 gene polymorphisms with plasma triglyceride and lipid levels.
Rev Assoc Med Bras (1992)
March 2023
Karabük Üniversitesi, Medical Faculty, Department of Medical Biology - Samsun, Turkey.
Objective: The aim of this study was to determine frequency and associations between APOA5 c.56C>G, -1131T>C, c.553G>T, and APOC3 -482C>T and SstI gene polymorphisms with hypertriglyceridemia.
View Article and Find Full Text PDFContribution of APOA5, APOC3, CETP, ABCA1 and SIK3 genetic variants to hypertriglyceridemia development in Mexican HIV-patients receiving antiretroviral therapy.
Pharmacogenet Genomics
April 2022
Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias, UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social, IMSS.
Article Synopsis
- This study investigates how specific gene variations (SNPs) affect the development of high triglyceride levels in HIV patients on antiretroviral therapy.
- A total of 602 patients were genotyped, revealing strong associations between hypertriglyceridemia and certain SNPs (notably rs964184 in APOA5) as well as factors like age and type of medication.
- The findings suggest that these genetic variations could play a significant role in the side effects experienced by HIV patients undergoing treatment with protease inhibitors.
Associations of Polygenetic Variants at the 11q23 Locus and Their Interactions with Macronutrient Intake for the Risk of 3GO, a Combination of Hypertension, Hyperglycemia, and Dyslipidemia.
J Pers Med
March 2021
Department of Bio-Convergence System, Hoseo University, Asan 31499, Korea.
3GO is a condition in which hypertension, hyperglycemia, and dyslipidemia co-occur, and these conditions are related to each other and genetic and environmental factors. We hypothesized that common genetic variants and their interactions with lifestyles influenced 3GO risk. We aimed to explore common genetic variants to affect 3GO risk and their haplotype interaction with lifestyles in a city hospital-based cohort in 58,701 Koreans > 40 years.
View Article and Find Full Text PDFFine genetic mapping of the chromosome 11q23.3 region in a Han Chinese population: insights into the apolipoprotein genes underlying the blood lipid-lipoprotein variances.
J Genet Genomics
December 2020
Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai and Shanghai Academy of Science and Technology, Shanghai 200025, China. Electronic address:
The unusual chromosome 11q23.3 harboring the apolipoprotein (APO) gene cluster has been well documented for its essential roles in plasma lipid-related traits and atherosclerotic cardiovascular diseases. However, its genetic architecture and the potential biological mechanisms underlying complex phenotypes have not been well assessed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!