The advantages of open, vertical-field, magnetic resonance-guided, focused ultrasound surgery (MRgFUS) are attractive. The inverse technique using the bi-boundary conditions is proposed to design a uterine-oriented intraoperative RF coil with an ultrasound aperture for the MRgFUS system. In the current proposed scheme, the desired magnetic field of the RF coil was set to completely overlap the target organ. The current density distribution on the RF coil surface, accounting for the expected magnetic field, was solved using the inverse technique. The stream function was available through the 'discretization' of the current density distribution on the RF coil surface. The coil windings were obtained from the contour plot of the stream function. As a modification of previous designs, the bi-boundary conditions are proposed in the inverse technique for the existence of the ultrasound aperture. Based on the obtained coil windings, a prototype coil was constructed. MR imaging of the phantom and the human body was performed to show the efficacy of the prototype coil. The results of temperature measurement using the prototype coil in a 0.4-T MR system were satisfactory. The performance of the prototype coil improved compared with the previously reported design.
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http://dx.doi.org/10.1016/j.mri.2012.05.009 | DOI Listing |
Pharmaceutics
December 2024
Department of Biopharmaceutics and Pharmaceutical Technology, Institute of Pharmacy, University of Greifswald, Felix-Hausdorff-Strasse 3, 17489 Greifswald, Germany.
The development of targeted drug delivery systems for active pharmaceutical ingredients with narrow absorption windows is crucial for improving their bioavailability. This study proposes a novel 3D-printed expandable drug delivery system designed to precisely administer drugs to the upper small intestine, where absorption is most efficient. The aim was to design, prototype, and evaluate the system's functionality for organ retention and targeted drug release.
View Article and Find Full Text PDFMagn Reson Imaging
January 2025
Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN 37232, USA. Electronic address:
Background: Inductively coupled wireless coils are increasingly used in MRI due to their cost-effectiveness and simplicity, eliminating the need for expensive components like preamplifiers, baluns, coil plugs, and coil ID circuits. Existing tools for predicting component values and electromagnetic (EM) fields are primarily designed for cylindrical volume coils, making them inadequate for irregular volume-type wireless coils.
Purpose: The aim of this study is to introduce and validate a novel magnetic (H-) field probe-based co-simulation method to accurately predict capacitance values and EM fields for irregular volume-type wireless coils, thereby addressing the limitations of current prediction tools.
IEEE J Solid-State Circuits
November 2024
Department of Electrical and Computer Engineering, Rice University, Houston TX, 77005, USA.
Miniature bioelectronic implants promise revolutionary therapies for cardiovascular and neurological disorders. Wireless power transfer (WPT) is a significant method for miniaturization, eliminating the need for bulky batteries in today's devices. Despite successful demonstrations of millimetric battery-free implants in animal models, the robustness and efficiency of WPT are known to degrade significantly under misalignment incurred by body movements, respiration, heart beating, and limited control of implant orientation during surgery.
View Article and Find Full Text PDFMed Phys
January 2025
Department of Electrical and Electronics Engineering, Bilkent University, Ankara, Turkey.
Background: Radiofrequency (RF) transmit arrays play a crucial role in various MRI applications, offering enhanced field control and improved imaging capabilities. Designing and optimizing these arrays, particularly in high-field MRI settings, poses challenges related to coupling, resonance, and construction imperfections. Numerical electromagnetic simulation methods effectively aid in the initial design, but discrepancies between simulated and fabricated arrays often necessitate fine-tuning.
View Article and Find Full Text PDFMatrix Biol
January 2025
Manchester Cell-Matrix Centre, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, UK; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, M13 9PL, United Kingdom. Electronic address:
Pentraxin-3 (PTX3) is an octameric protein, comprised of eight identical protomers, that has diverse functions in reproductive biology, innate immunity and cancer. PTX3 interacts with the large polysaccharide hyaluronan (HA) to which heavy chains (HCs) of the inter-α-inhibitor (IαI) family of proteoglycans are covalently attached, playing a key role in the (non-covalent) crosslinking of HC•HA complexes. These interactions stabilise the cumulus matrix, essential for ovulation and fertilisation in mammals, and are also implicated in the formation of pathogenic matrices in the context of viral lung infections.
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