AI Article Synopsis
- The study examines the link between IL1 gene polymorphisms and the risk of chronic kidney disease (CKD) and periodontitis (PD), suggesting that specific genetic variations in these genes can increase susceptibility to these conditions.
- Researchers analyzed DNA from oral mucosa and found that certain alleles, such as IL1RN(*)1 and IL1RN(*)2, are significantly associated with heightened risk for CKD and PD, respectively.
- The findings indicate that higher levels of IL1 gene transcripts are present in patients with periodontitis, which could suggest a shared inflammatory pathway influencing both CKD and PD.
Article Abstract
Unlabelled: Chronic kidney disease (CKD) and periodontitis (PD) are complex inflammatory disturbances, influenced by genetic factors. Interleukin (IL)-1 genes code for inflammatory mediators involved in the physiopathogenesis of both diseases. Functional polymorphisms in IL1 genes modulate cytokine levels and have been associated with susceptibility to immune-inflammatory conditions.
Objectives: The aim of this study was investigate the association of functional IL1 gene polymorphisms and transcript levels with susceptibility to CKD and PD.
Design: The sample consisted of 246 individuals, mean age 44.8 years, divided into: group 1 (64 patients without CKD and without PD), group 2 (58 without CKD and with PD), group 3 (52 with CKD and without PD) and group 4 (72 with CKD and with PD). DNA was obtained from cells of oral mucosa and polymorphisms IL1AC-889T, IL1BC-511T, IL1BC+3954T and IL1RN (intron 2) were analyzed by PCR-RFLP. Transcript levels from gingival tissues were analyzed by real-time PCR.
Results: IL1RN(*)1 allele was associated with almost 4-fold increased risk for CKD (OR 3.92 95% CI=1.6-9.4, p=0.002). IL1RN(*)2 allele was associated with 3-fold increased risk for PD in CKD patients (OR 3.08 95% CI=1.2-7.9, p=0.019). Allele T for polymorphism IL1B+3954 was associated with CKD in PD patients (OR 2.28 95% CI=1.1-4.7, p=0.019). Significantly increased levels of transcripts of IL1A, IL1B and IL1RN genes were found in PD patients.
Conclusions: It was observed an evidence for association of IL1B and IL1RN alleles with susceptibility to CKD and PD. Higher levels of IL1 gene transcripts were found in PD patients.
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| http://dx.doi.org/10.1016/j.cyto.2012.06.006 | DOI Listing |
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