AI Article Synopsis
- The study aimed to find links between the interleukin-1β gene and preeclampsia in Taiwanese women.
- Researchers analyzed 102 women with preeclampsia and 148 control women for genetic variations using specific testing methods.
- Results showed no significant association between the interleukin-1β gene variations and preeclampsia, indicating it may not play a role in this condition among the studied population.
Article Abstract
Objective: To identify associations between the interleukin-1β gene and preeclampsia in Taiwanese women.
Methods And Materials: We genotyped Taiwanese population (102 women with preeclampsia and 148 controls) for two polymorphisms of the interleukin-1β gene (promoter region and Exon 5) by using polymerase chain reaction and restriction fragment length polymorphism analysis. The association between the genotype and disease was examined by Chi-square tests.
Results: We found no association between the two polymorphic sites of interleukin-1β gene and preeclampsia. No significant differences were detected in genotype distributions and allele frequencies of the AvaI polymorphism at position -511 in the promoter region and the TaqI polymorphism at position +3953 within Exon 5.
Conclusion: Our data do not support a role of the interleukin-1β gene in the pathogenesis of preeclampsia in Taiwanese women.
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| http://dx.doi.org/10.1016/j.tjog.2012.04.014 | DOI Listing |
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