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Inhibition of mitochondrial OMA1 ameliorates osteosarcoma tumorigenesis.
Cell Death Dis
November 2024
Department of Orthopedics, Affiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, Guangdong, China.
OMA1 is an ATP-independent zinc metalloprotease essential for maintaining mitochondrial homeostasis and plays a vital role in tumorigenesis. Depending on the type of cancer, a decrease in OMA1 expression has been linked to a varying prognosis for patients. The role of OMA1 in human osteosarcoma (OS), one of the most prevalent malignant bone tumors, remains elusive.
View Article and Find Full Text PDFAdsorption of drugs on BN and AlN nanocages.
RSC Adv
October 2024
Physical Science and Engineering Division (PSE), Computational Transport Phenomena Laboratory, King Abdullah University of Science and Technology (KAUST) Thuwal 23955-6900 Saudi Arabia
The adsorption behavior of twelve drug molecules (5-fluorouracil, nitrosourea, pyrazinamide, sulfanilamide, ethionamide, 6-thioguanine, ciclopirox, 6-mercaptopurine, isoniazid, metformin, 4-aminopyridine, and cathinone) on BN and AlN nanocages was studied using density functional theory. In general, the drug molecules prefer to bind with the boron atom of the BN nanocage and the aluminium atoms of the AlN nanocage. However, a hydrogen atom is transferred from each of 5-fluorouracil, nitrosourea, 6-thioguanine, ciclopirox, and 6-mercaptopurine to the nitrogen atom of the AlN nanocage.
View Article and Find Full Text PDFExploration of the link between COVID-19 and gastric cancer from the perspective of bioinformatics and systems biology.
Front Med (Lausanne)
September 2024
Division of Liver Surgery, Department of General Surgery and Laboratory of Liver Surgery, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Background: Coronavirus disease 2019 (COVID-19), an infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has caused a global pandemic. Gastric cancer (GC) poses a great threat to people's health, which is a high-risk factor for COVID-19. Previous studies have found some associations between GC and COVID-19, whereas the underlying molecular mechanisms are not well understood.
View Article and Find Full Text PDFInvestigation of the relationship between COVID-19 and pancreatic cancer using bioinformatics and systems biology approaches.
Medicine (Baltimore)
August 2024
Department of Hepatobiliary and Pancreatic Surgery, Minda Hospital of Hubei Minzu University, Enshi, P.R. China.
Background: The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, poses a huge threat to human health. Pancreatic cancer (PC) is a malignant tumor with high mortality. Research suggests that infection with SARS-CoV-2 may increase disease severity and risk of death in patients with pancreatic cancer, while pancreatic cancer may also increase the likelihood of contracting SARS-CoV-2, but the link is unclear.
View Article and Find Full Text PDFCiclopirox inhibits SARS-CoV-2 replication by promoting the degradation of the nucleocapsid protein.
Acta Pharm Sin B
June 2024
Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen 518112, China.
The nucleocapsid protein (NP) plays a crucial role in SARS-CoV-2 replication and is the most abundant structural protein with a long half-life. Despite its vital role in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) assembly and host inflammatory response, it remains an unexplored target for drug development. In this study, we identified a small-molecule compound (ciclopirox) that promotes NP degradation using an FDA-approved library and a drug-screening cell model.
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