AI Article Synopsis
- Small-animal PET imaging is super important for studying cancer and testing new treatments on animals.
- Researchers need to plan their experiments carefully so they can get good results and compare treated animals to control groups effectively.
- The paper talks about ways to improve imaging by using special setups that can scan multiple animals at once and explains some challenges that come up when imaging several animals together.
Article Abstract
Over the last decade, small-animal PET imaging has become a vital platform technology in cancer research. With the development of molecularly targeted therapies and drug combinations requiring evaluation of different schedules, the number of animals to be imaged within a PET experiment has increased. This paper describes experimental design requirements to reach statistical significance, based on the expected change in tracer uptake in treated animals as compared to the control group, the number of groups that will be imaged, and the expected intra-animal variability for a given tracer. We also review how high-throughput studies can be performed in dedicated small-animal PET, high-resolution clinical PET systems and planar positron imaging systems by imaging more than one animal simultaneously. Customized beds designed to image more than one animal in large-bore small-animal PET scanners are described. Physics issues related to the presence of several rodents within the field of view (i.e. deterioration of spatial resolution and sensitivity as the radial and the axial offsets increase, respectively, as well as a larger effect of attenuation and the number of scatter events), which can be assessed by using the NEMA NU 4 image quality phantom, are detailed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411308 | PMC |
| http://dx.doi.org/10.1007/s00259-012-2177-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Optimized automated radiosynthesis of F-JNJ64413739 for purinergic ion channel receptor 7 (P2X7R) imaging in osteoporotic model rats.
Front Pharmacol
December 2024
Department of Nuclear Medicine, The First Affiliated Hospital, Jinan University, Guangzhou, China.
Objective: To optimize the automated radiosynthesis of the purinergic ion channel receptor 7 (P2X7R) imaging agent F-JNJ64413739 and evaluate its potential for brain imaging in osteoporotic model rats.
Methods: A more electron-deficient nitropyridine was employed as the labeling precursor to facilitate the F-labeling. The radiosynthesis was conducted on an AllinOne synthesis module, and followed by purification via high-performance liquid chromatography (HPLC).
Case report: Treatment of non-medical tetrahydrocannabinol toxicosis with transmucosal cannabidiol-infused dissolving sheets in six dogs.
Front Vet Sci
December 2024
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, United States.
Increased cases of canine tetrahydrocannabinol (THC) toxicosis have been reported in North America in recent years. Cases are often evaluated on an emergency basis and treatment has relied upon supportive care which can be costly and prohibitive for some pet owners. The purpose of this report is to describe the clinical findings and outcomes in dogs with non-medical, presumptive THC toxicosis treated by administration of a cannibidiol (CBD)-infused transmucosal dissolving sheet.
View Article and Find Full Text PDFObjective: Direct-to-consumer (D2C) genetic tests are increasingly accessible to pet owners, with commercial genetic companies entering veterinary distribution markets. This study evaluated veterinary care providers' (VCPs) awareness of the D2C genetic industry, experiences with clients' inquiries, perceptions of clinical utility, and confidence in interpreting test results.
Methods: Veterinary care providers attending a professional conference (February 19 through 23, 2023) were invited to complete an online survey.
High spatial resolution PET detectors based on 10 mm × 10 mm linearly-graded SiPMs and 0.5 mm pitch LYSO arrays.
Phys Med Biol
December 2024
Department of Biomedical Engineering, University of California Davis, 451 East Health Science Drive, Davis, California, 95616, UNITED STATES.
Position-sensitive silicon photomultipliers (PS-SiPMs) are promising photodetectors for ultra-high spatial resolution small-animal positron emission tomography (PET) scanners. This paper evaluated the performance of the latest generation of linearly-graded SiPMs (LG-SiPMs), a type of PS-SiPM, for ultra-high spatial resolution PET applications using LYSO arrays from two vendors. Approach: Two dual-ended readout detectors were developed by coupling LG-SiPMs to both ends of the two LYSO arrays.
View Article and Find Full Text PDFArterial effects of anthracycline: structural & inflammatory assessments in non-human primates and lymphoma patients.
Clin Sci (Lond)
December 2024
University of Glasgow BHF Glasgow Cardiovascular Research Centre, Glasgow, United Kingdom.
Anthracyclines, such as doxorubicin, are important anti-cancer therapies but are associated with arterial injury. Histopathological insights have been limited to small animal models and the role of inflammation in the arterial toxic effects of anthracycline is unclear in humans. Our aims were: 1) To evaluate aortic media fibrosis and injury in non-human primates treated with anthracyclines; 2) To assess the effect of anthracycline on aortic inflammation in patients treated for lymphoma.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!