AI Article Synopsis
- Ovarian cancer is a leading cause of death from gynecological cancers, with conventional treatments offering limited long-term success.
- Recent research is shifting toward targeted therapies like PARP inhibitors, particularly Olaparib, which have the potential to effectively kill tumors while reducing side effects.
- Studies show that Olaparib shows promise in treating ovarian cancer, especially in patients with BRCA1 and BRCA2 mutations, but more research is necessary to validate these encouraging findings.
Article Abstract
Introduction: Ovarian cancer is the most important cause of gynecological cancer-related mortality. Conventional treatments for advanced or recurrent disease offer limited results in terms of long-term responses and survival. Researches have recently focused on target therapies, which represent a new, promising, therapeutic approach, able to maximizing tumor kill and minimizing toxicity. The family of polyadenosine diphosphate-ribose polymerase (PARP) inhibitors is currently one of the most hopeful and investigated alternatives.
Areas Covered: Preclinical and clinical studies of Olaparib , the most investigated PARP inhibitor in ovarian cancer, are analyzed and discussed. Data were obtained by searching for all English peer-reviewed articles on Medline, on Cochrane Database and all on-going Phase I and II studies registered on National Cancer Institute Clinical Trials; also any related abstracts recently presented on Olaparib at major international congresses will be included.
Expert Opinion: Bad prognosis and drug resistance usually affect ovarian cancer. Recent trends toward the knowledge of molecular-specific pathways have produced new target drugs. PARP inhibition mediated by Olaparib in BRCA1 (breast cancer 1) and BRCA2 (breast cancer 2)-mutated and in sporadic ovarian cancer represents a promising field of investigation. Further studies are needed to confirm initial exciting results.
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| http://dx.doi.org/10.1517/13543784.2012.707189 | DOI Listing |
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