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The recent landscape of RSV vaccine research.
Ther Adv Vaccines Immunother
January 2025
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, OX1 2JD, UK.
Respiratory syncytial virus (RSV) causes a significant burden of acute respiratory illness across all ages, particularly for infants and older adults. Infants, especially those born prematurely or with underlying health conditions, face a high risk of severe RSV-related lower respiratory tract infections (LRTIs). Globally, RSV contributes to millions of LRTI cases annually, with a disproportionate burden in low- and middle-income countries (LMICs).
View Article and Find Full Text PDFMechanisms underlying EEG power changes during wakefulness in insomnia patients: a model-driven study.
Cogn Neurodyn
December 2025
The Medical Big Data Research Center, Northwest University, Xi'an, 710127 China.
Insomnia, as a common sleep disorder, is the most common complaints in medical practice affecting a large proportion of the population on a situational, recurrent or chronic basis. It has been demonstrated that, during wakefulness, patients with insomnia exhibit increased EEG power in theta, beta, and gamma band. However, the relevant mechanisms underlying such power changes are still lack of understanding.
View Article and Find Full Text PDFJohn the Baptist in Leonardo Da Vinci's Painting - What's in a Smile?
Clin Dermatol
January 2025
Agnes Irwin School. Rosemont, Pennsylvania, USA.
The smile is a complex human facial expression, most commonly associated with joy. We present a detailed view on Leonardo Da Vinci's painting of Saint John the Baptist, between 1516 to 1516, which illustrates a smiling saint, which has evoked multiple explanations and theories. Discussing Da Vinci's concept of painting as science media and the two merely contradictory painting techniques chiaroscuro and sfumato, we attempt to approach this picture.
View Article and Find Full Text PDFRNA Interference in Amyloid: What's New From HELIOS-B?
J Cardiothorac Vasc Anesth
December 2024
Department of Anesthesiology and Perioperative Medicine, Penn State Health Milton S Hershey Medical Center, Hershey, PA.
A study protocol for individualized prognostic counselling in the palliative phase.
BMC Palliat Care
January 2025
Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute, University Medical Centre Rotterdam, Dr. Molewaterplein 40, Rotterdam, 3015 GD, The Netherlands.
Background: Head and neck squamous cell cancer (HNSCC) has a poor prognosis, with approximately 25-30% of patients transitioning into the palliative phase at some point. The length of this phase is relatively short, with a median duration of five months. Patients in this stage often have increased prognostic information needs.
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