AI Article Synopsis
- HCN channels, linked to psychosis risk, are encoded by four genes (HCN1-4) and activated by cyclic AMP (cAMP).
- A study aimed to determine if genetic variations in these genes are associated with depression or cognitive impairment in a Scottish population.
- The findings showed no significant links between the genetic variations in HCN channels and the risks of depression, neuroticism, or cognitive performance.
Article Abstract
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are encoded by four genes (HCN1-4) and, through activation by cyclic AMP (cAMP), represent a point of convergence for several psychosis risk genes. On the basis of positive preliminary data, we sought to test whether genetic variation in HCN1-4 conferred risk of depression or cognitive impairment in the Generation Scotland: Scottish Family Health Study. HCN1, HCN2, HCN3, and HCN4 were genotyped for 43 haplotype-tagging SNPs and tested for association with DSM-IV depression, neuroticism, and a battery of cognitive tests assessing cognitive ability, memory, verbal fluency, and psychomotor performance. No association was found between any HCN channel gene SNP and risk of depression, neuroticism, or on any cognitive measure. The current study does not support a genetic role for HCN channels in conferring risk of depression or cognitive impairment in individuals from the Scottish population.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387669 | PMC |
| http://dx.doi.org/10.3389/fgene.2012.00116 | DOI Listing |
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