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A Proof-of-Concept Study of Ulipristal Acetate for Early Medication Abortion.
NEJM Evid
February 2025
Gynuity Health Projects, New York.
Background: The current regimen for early medication abortion in many countries is mifepristone and misoprostol, but mifepristone is relatively expensive and limited in many regions. Ulipristal acetate, with a similar chemical profile, might be an alternative. This proof-of-concept study evaluated ulipristal acetate and misoprostol for medication abortion through 63 days of gestation.
View Article and Find Full Text PDFThe contraceptive active ingredient levonorgestrel disrupts the physiology of Macrocyclops albidus.
Environ Pollut
February 2025
Department of Ecology, University of Brasília, Brazil. Electronic address:
Active pharmaceutical ingredients, such as levonorgestrel (LNG), continue to increase in aquatic ecosystems and are detected in environmental matrices; however, their ability to bioaccumulate and cause reproductive, developmental, and biochemical defects in benthic organisms, such as Macrocyclops albidus, is unknown. This study investigated the effects of LNG on the oxidative stress response, reproduction, and development of M. albidus.
View Article and Find Full Text PDFIntensifying intermittent aeration for optimizing nutrient and hormone removal in vertical-flow constructed wetlands filled with aerated concrete.
Chemosphere
February 2025
Federal University of Tecnhology - Paraná (UTFPR) - Civil Construction Academic Department, Deputado Heitor de Alencar Furtado St., 5000, Ecoville, 81280-340, Curitiba, Paraná, Brazil. Electronic address:
Operational strategies have been applied in constructed wetlands to optimize the removal of nutrients and hormones that are still a concern in wastewater treatment. The strategy of intensifying intermittent aeration was investigated in two microcosm-scale vertical-flow constructed wetlands (VFCWs) planted with Eichhornia crassipes onto autoclaved aerated concrete (AC) in the removal of nutrients, estrone (E1), 17β-estradiol (E2) and 17α-ethinylestradiol (EE2). CW-1 (2.
View Article and Find Full Text PDFEstrogen administration enhances the adverse effects of cigarette smoking on the heart in cycling female mice.
Biol Sex Differ
December 2024
Department of Pharmacology and Toxicology, American University of Beirut Faculty of Medicine, American University of Beirut & Medical Center, Riad El-Solh, Beirut, 11072020, Lebanon.
Article Synopsis
- - Smoking, especially chronic smoking, poses a significant health risk by increasing the chances of heart-related diseases and causing damage to the heart's structure and function through oxidative stress and endothelial dysfunction.
- - This study examines how chronic cigarette smoke interacts with the oral contraceptive ethinylestradiol in premenopausal females, revealing that their combination leads to negative changes in heart structure, such as larger left ventricular size and increased heart mass.
- - Results indicate that this combination triggers an inflammatory response, with elevated inflammatory markers and collagen deposition, suggesting it may lead to heart conditions similar to dilated cardiomyopathy.
Development of breakthrough bleeding model of combined-oral contraceptives utilizing model-based meta-analysis.
CPT Pharmacometrics Syst Pharmacol
November 2024
Department of Pharmaceutics, College of Pharmacy, Center for Pharmacometrics and Systems Pharmacology, University of Florida, Orlando, Florida, USA.
Article Synopsis
- Breakthrough bleeding (BTB) is a common side effect of hormonal contraceptives, particularly combined oral contraceptives (COCs), and can affect user adherence.
- A model-based meta-analysis was conducted using data from 25 studies to investigate the dose-response relationship of different progestin/ethinyl estradiol (EE) combinations and their effects on BTB.
- Results indicate that BTB increases when starting COCs but generally returns to baseline within 3 months, especially at higher EE doses; understanding these relationships can aid in optimizing COC treatment regimens.
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