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Clinical improvement in a patient with neuromyelitis optica following therapy with the anti-IL-6 receptor monoclonal antibody tocilizumab. | LitMetric
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Clinical improvement in a patient with neuromyelitis optica following therapy with the anti-IL-6 receptor monoclonal antibody tocilizumab.

Manabu Araki Toshimasa Aranami Takako Matsuoka Masakazu Nakamura Sachiko Miyake Takashi Yamamura

Mod Rheumatol

Multiple Sclerosis Center, National Center Hospital, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan.

Published: July 2013

Neuromyelitis optica (NMO) is a disabling autoimmune disease associated with an elevation of anti-aquaporin 4 (AQP4) autoantibodies. Here, we present a case with NMO who responded to monthly administration of the anti-IL-6 receptor antibody tocilizumab. The treatment rapidly reduced the elevated numbers of plasmablasts and anti-AQP4 autoantibodies in the patient. Furthermore, neuropathic pain and disability scores gradually improved. Tocilizumab may be considered as a therapeutic option for NMO.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713263PMC
http://dx.doi.org/10.1007/s10165-012-0715-9DOI Listing

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