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Environmental pollutants and bad bugs work hand in glove.
Trends Cancer
October 2024
Institution of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang Province, 310058, China; Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang Province, 310058, China. Electronic address:
'Bad bacteria' could alter the toxicokinetics of environmental pollutants, thereby exacerbating chemically induced tumorigenesis. Recently, Roje et al. reported that specific gut microbiota can metabolize nitrosamine compounds to a toxic oxidation product, aggravating bladder cancer development and progression.
View Article and Find Full Text PDFHow to set up and run a Bad Bugs Bookclub group.
Access Microbiol
September 2024
Department of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, M1 5GD, UK.
The Bad Bugs Bookclub is a public engagement initiative that enables scientists (microbiologists) and non-scientists to discuss the role of infectious disease and microorganisms in novels of fiction. The bookclub began in 2009, but since 2020, the meetings have taken place online, enabling international membership and occasional author participation. The bookclub has been shown, through peer-reviewed publications, to have impact and value to its members.
View Article and Find Full Text PDFPublic and media interest in bed bugs-Europe 2023.
Curr Res Insect Sci
April 2024
Natural History Museum Vienna, Burgring 7, 1010 Vienna, Austria.
In late summer of 2023 bed bug () infestations received much media attention especially from Paris Fashion Week (2023-09-25/2023-10-03). Concern in France has grown in recent years and the public may have been sensitised from the recent release of the report from the Agence Nationale de Sécurité Sanitaire. Additionally, families returning from summer travel for the start of the school year (2023-09-04) may have brought spp.
View Article and Find Full Text PDFImproved understanding of biorisk for research involving microbial modification using annotated sequences of concern.
Front Bioeng Biotechnol
April 2023
Schar School of Policy and Government, George Mason University, Arlington, VA, United States.
Regulation of research on microbes that cause disease in humans has historically been focused on taxonomic lists of 'bad bugs'. However, given our increased knowledge of these pathogens through inexpensive genome sequencing, 5 decades of research in microbial pathogenesis, and the burgeoning capacity of synthetic biologists, the limitations of this approach are apparent. With heightened scientific and public attention focused on biosafety and biosecurity, and an ongoing review by US authorities of dual-use research oversight, this article proposes the incorporation of sequences of concern (SoCs) into the biorisk management regime governing genetic engineering of pathogens.
View Article and Find Full Text PDFOptimizing Antimicrobial Therapy by Integrating Multi-Omics With Pharmacokinetic/Pharmacodynamic Models and Precision Dosing.
Front Pharmacol
June 2022
Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur, Malaysia.
In the era of "," optimizing antibiotic therapy against multi-drug resistant (MDR) pathogens is crucial. Mathematical modelling has been employed to further optimize dosing regimens. These models include mechanism-based PK/PD models, systems-based models, quantitative systems pharmacology (QSP) and population PK models.
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