AI Article Synopsis
- HIV type-1 is a virus that specifically infects humans, making research difficult without suitable small-animal models.
- In 2004, researchers developed a new humanised mouse model by injecting human cord blood cells into newborn immunodeficient mice, allowing them to effectively mimic human HIV infection.
- This review will discuss different humanised mouse models and their importance in advancing our understanding of HIV infection.
Article Abstract
The human immunodeficiency virus (HIV) type-1 is a human-specific virus. The lack of a widely available small-animal model has seriously hampered HIV research. In 2004, a new humanised mouse model was reported. It was based on the intrahepatic injection of human CD34+ cord blood cells into newborn, highly immunodeficient mice. These mice develop a lymphoid system of human origin and are highly susceptible to HIV infection and showed disseminated infection, persistent viraemia and characteristic helper CD4+ T-cell loss. Here, we will briefly review the various existing humanised mouse models and highlight their value to the study of HIV infection.
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| http://dx.doi.org/10.4414/smw.2012.13618 | DOI Listing |
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