Molecular biology and clinical features of hereditary non-polyposis colorectal cancer.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao

Department of Multimodality Therapy Oncology, Chinese PLA Hospital, Beijing 100853, China.

Published: June 2012

Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominantly inherited disease associated with germ-line mutations in mismatch repair genes and microsatellite instability. This article reviews the molecular biology and clinical pathology of HNPCC.

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http://dx.doi.org/10.3881/j.issn.1000-503X.2012.03.021DOI Listing

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