AI Article Synopsis
- Polycomb group (PcG) proteins help regulate gene expression, specifically repressing genes during stem cell growth and differentiation.
- The PcG family includes two key complexes: PRC1 and PRC2, which play crucial roles in this regulation.
- The review focuses on understanding the composition, localization, recruitment, and overall functions of PcG proteins in stem cell development.
Article Abstract
Polycomb group (PcG) proteins are a family of epigenetic regulators responsible for the repression of genes in proliferation and differentiation of stem cells. PcG protein complex consists of two important epigenetic regulators: PRC1 (polycomb repressive complex 1) and PRC2 (polycomb repressive complex 2). In order to further understand the functions of PcG proteins in stem cell growth and differentiation, we review the PcG protein composition, PcG protein localization in the target gene, PcG protein recruitment, and the functions of PcG proteins in the development of stem cells.
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| http://dx.doi.org/10.3881/j.issn.1000-503X.2012.03.019 | DOI Listing |
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