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Epigenetic Biomarkers in Thrombophilia-Related Pregnancy Complications: Mechanisms, Diagnostic Potential, and Therapeutic Implications: A Narrative Review.
Int J Mol Sci
December 2024
Department of Obstetrics and Gynecology, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Pregnancy complications associated with thrombophilia represent significant risks for maternal and fetal health, leading to adverse outcomes such as pre-eclampsia, recurrent pregnancy loss, and intra-uterine growth restriction (IUGR). They are caused by disruptions in key physiological processes, including the coagulation cascade, trophoblast invasion, angiogenesis, and immune control. Recent advancements in epigenetics have revealed that non-coding RNAs, especially microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and extracellular vesicles (EVs) carrying these RNAs, play crucial roles in the regulation of these biological processes.
View Article and Find Full Text PDFEffect of maternal beta-blocker treatment on mean fetal heart rate.
AJOG Glob Rep
February 2025
Assistance Publique-Hôpitaux de Paris, Service de Gynécologie-Obstétrique, Hôpital Bicêtre, Université Paris Saclay, Le Kremlin-Bicetre, France (Hautier and Luton).
Background: During pregnancy, the prescription of beta-blockers to the mother may be necessary for pre-existing chronic conditions. Their use raises concerns due to potential effects on the fetus.
Objectives: This study aimed to investigate the impact of beta-blockers on mean fetal heart rate in pregnant women treated with these medications compared to an untreated patient group.
Risk Factors for Antepartum Haemorrhage in Women With Placenta Praevia.
Aust N Z J Obstet Gynaecol
January 2025
Obstetrics and Gynaecology, Mater Mothers Hospital, Brisbane, Queensland, Australia.
Background: Placenta praevia (PP) is a significant obstetric complication associated with antepartum haemorrhage (APH) and adverse maternal and fetal outcomes. Identifying risk factors for APH in women with PP is important for guiding management decisions.
Aims: This study aimed to identify risk factors associated with APH amongst women admitted to a single tertiary hospital with PP.
Relationships between Fetal and Neonatal Outcomes and Spectrum of COVID-19 Disease in Pregnant Women.
Tanaffos
January 2024
Department of Epidemiology, Faculty of Medical Sciences, Qom University of Medical Sciences, Qom, Iran.
Background: Due to the high prevalence of COVID-19 and the prevention and control of adverse fetal and neonatal outcomes in pregnant women, including vertical transmission, this study was performed to describe the fetal and neonatal outcomes of pregnancy with a spectrum of COVID-19 disease during pregnancy in Iran.
Materials And Methods: In this cross-sectional study, we analyzed the medical records of 258 pregnant women admitted to the Forghani Hospital, Qom, Iran, from 18 February 2020, to May 10, 2021. PCR-RT or respiratory compromise in the presence of marked radiographic changes of COVID-19 in the lungs, or both COVID-19 disease confirmed COVID-19 disease.
Aberrant expression of solute carrier family transporters in placentas associated with pregnancy complications.
Placenta
January 2025
Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India. Electronic address:
Article Synopsis
- The study investigates the role of solute carrier family transporters (SLCs) in the placenta, linking their dysregulation to pregnancy disorders like preeclampsia (PE) and intrauterine growth restriction (IUGR).
- Researchers conducted a meta-analysis of public data and verified findings through qPCR, focusing on differentially expressed SLCs in PE and IUGR samples.
- The results showed significant downregulation of specific SLCs (SLC6A8, SLC16A10, SLC25A3, SLC29A3) in affected placental samples, suggesting their potential role in the pathogenesis of these pregnancy complications.
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