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Dispensing of zolpidem and benzodiazepines in Brazilian private pharmacies: a retrospective cohort study from 2014 to 2021.

Front Pharmacol

November 2024

Programa de Pós-Graduação em Epidemiologia, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Objective: The study aimed to evaluate Zolpidem and Benzodiazepines prescription and dispensing data in private pharmacies in Brazil from 2014 to 2021. Methods: This retrospective cohort study was carried out with retrospective open data from the Brazilian Federal Government from January 2014 to August 2021 containing medicines registered in the National Controlled Products Management System (SNGPC).

Results: Between January 2014 and August 2021, a total of 32,441,392 sales of thirteen drugs from the z-drug and benzodiazepine classes used to treat sleep disorders were recorded in Brazil.

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Fatal pregabalin poisoning in Japan: A case report.

Leg Med (Tokyo)

November 2024

Department of Forensic Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Article Synopsis
  • * A fatal case in Japan revealed that a patient with multiple prescriptions, including pregabalin, overdosed; while initial screenings missed pregabalin, further tests confirmed its presence at a dangerous level.
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Social network analysis for medical narcotics in South Korea: focusing on patients and healthcare organizations.

BMC Health Serv Res

May 2024

Department of Industrial Engineering, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-gu, Seoul, 139-743, Republic of Korea.

Background: Medical narcotics must be administered under medical supervision because of their potential for misuse and abuse, leading to more dangerous and addictive substances. The control of medical narcotics requires close monitoring to ensure that they remain safe and effective. This study proposes a methodology that can effectively identify the overprescription of medical narcotics in hospitals and patients.

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Zolpidem Stimulant Effect and Dependence: A Case Report on Intranasal Use.

Psychopharmacol Bull

April 2024

Alaber, MD, Department of Psychiatry, University Hospital Dubrava, Avenija Gojka Šuška, Zagreb, Croatia.

Zolpidem is a widely used hypnotic. Dependence on zolpidem due to the induction of euphoria is a rare condition, while intranasal misuse of zolpidem is a rather new phenomenon. We present the first case of a patient who developed zolpidem dependence, which was associated with the prompt onset of euphoria exclusively following intranasal use.

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Z-Drug Use and Benzodiazepine Use and Misuse Among LGB Populations: The Role of Psychological Distress.

J Addict Med

July 2024

From the Department of Psychiatry, Universidade Federal de Sao Paulo, Sao Paulo, Brazil (VST, TMF); and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (SSM).

Background: Z-drugs (hypnotics such as zolpidem, zopiclone, and zaleplon) and benzodiazepines (BZDs) are sedative medications with misuse liability. The goals of this study are to report the (1) prevalence of past-year any Z-drug use, any BZD use, and any BZD misuse by sexual identity category and psychological distress; (2) associations among these 3 categories between sexual identity and past-year psychological distress; (3) associations among these 3 categories with sexual identity by past-year psychological distress status.

Methods: Data were collected from the National Survey on Drug Use and Health (years 2015-2019 [n = 210,392]), a yearly representative national household survey of the American population.

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