Two new sulfated oleanan saponins from Achyranthes root.

J Nat Med

Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan.

Published: April 2013

Two new sulfated oleanan saponins, sulfachyranthosides B (1) and D (2), were isolated from a water extract of Achyranthes root (root of Achyranthes bidentata). The structures were determined by analyses of spectroscopic data to be sulfates of achyranthosides B and D, respectively, at the 4'-position of the glucose moiety attached to the C-28 carboxylic acid of oleanolic acid.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11418-012-0684-5DOI Listing

Publication Analysis

Top Keywords

sulfated oleanan
8
oleanan saponins
8
achyranthes root
8
saponins achyranthes
4
root sulfated
4
saponins sulfachyranthosides
4
sulfachyranthosides isolated
4
isolated water
4
water extract
4
extract achyranthes
4

Similar Publications

In connection with our interest in the phytochemical investigation of Oliv. (Elaeocarpaceae) growing in Vietnam, two new sulphated oleanane triterpenes were obtained herein and structurally identified. Based on the combination of the extensive 1D-, 2D NMR and HR ESI MS spectroscopic data analysis, their chemical structures have been elucidated as 1,3-dihydroxy-olean-18-ene 1-sulphate () and 1,3-dihydroxy-olean-12-ene 1-sulphate ().

View Article and Find Full Text PDF

Gypsophila saponins enhance the cytotoxicity of etoposide in HD-MY-Z lymphoma cells.

Food Chem Toxicol

November 2019

Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav St, 1000, Sofia, Bulgaria.

Glucuronide Oleanane-type Triterpenoid Carboxylic Acid 3,28-Bidesmosides (GOTCAB) are accumulated in Gypsophila L. roots. In the study we aimed at investigating the possible synergistic effects of Gypsophila trichotoma GOTCABs and cytostatic etoposide towards the Hodgkin lymphoma cell line HD-MY-Z.

View Article and Find Full Text PDF

Eleven New Triterpenoid Glycosides from the Roots of Ilex asprella.

Chem Biodivers

July 2019

Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632, P. R. China.

Asprellosides A-K, nine new ursane-type triterpenoid glycosides (1-9), and two new oleanane-type triterpenoid glycosides (10 and 11), including six rare sulfated triterpenoid glycosides, were isolated from the roots of Ilex asprella. Their structures were determined on the basis of comprehensive spectroscopic analysis and chemical methods. Among these compounds, asprelloside B (2) and asprelloside C (3) are the first examples of triterpenoid glycosides bearing a rare 3,4-O-disulfo-xylopyranosyl residue.

View Article and Find Full Text PDF

Glucuronide Oleanane-type Triterpenoid Carboxylic Acid 3, 28-Bidesmosides (GOTCAB) saponins are bioactive natural compounds spread in Caryophyllidae. The high complexity of GOTCAB occurring as closely related isobaric and positional isomers is a challenge in their separation and identification. A new liquid chromatography - high resolution Orbitrap mass spectrometry acquisition strategy would be important for the structural elucidation of GOTCAB in plant extracts.

View Article and Find Full Text PDF

Introduction: Roots of Gypsophila trichotoma Wend. (Caryophyllaceae) are rich sources of glucuronide oleanane-type triterpenoid carboxylic acid 3,28-O-bidesmosides (GOTCABs). These saponins have been reported to possess synergistic cytotoxicity in combination with type I ribosome-inactivating protein saporin.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!