A brief history of endomyocardial biopsy as seen through the personal experience is herein reported. After 60 years from its introduction in clinical practice, the procedure still maintains its value as a tool for diagnosis and research, provided it is performed in qualified centers.
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http://dx.doi.org/10.2459/JCM.0b013e328356a516 | DOI Listing |
ESC Heart Fail
March 2025
Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Aims: The prevalences of aortic stenosis (AS) and transthyretin amyloid cardiomyopathy (ATTR-CM) increase with age. Identification of occult ATTR-CM in patients with AS can help explain out-of-proportion myocardial dysfunction, aid in prognostication and prompt initiation of disease-modifying treatment. Studies have suggested that many patients referred for transcatheter aortic valve implantation (TAVI) have concomitant ATTR-CM, but some have included unverified ATTR-CM in patients with ambiguous scintigrams.
View Article and Find Full Text PDFCardiol J
March 2025
Cardiology Department, Hospital General Universitario Gregorio Marañon, Faculty of Medicine, Universidad Complutense de Madrid and CIBERCV, Madrid, Spain.
Am J Cardiol
March 2025
Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Health Care, Iowa City, Iowa, USA.
Circ Heart Fail
March 2025
Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora. (N.L.A., E.A.G., L.K.M., J.A.W., A.K.-F., W.A.M., I.A.C., E.R.J., D.S., S.L.E., M.R.G.T., S.L.G., L.M., T.A.M., P.M.B., D.P.K., M.R.B.).
Background: Heart rate (HR) affects heart failure outcomes, via uncertain mechanisms that may include left ventricular remodeling. However, in human ventricular myocardium, HR change has not been associated with a particular remodeling molecular phenotype.
Methods: Patients with nonischemic dilated cardiomyopathy (N=22) in sinus rhythm and refractory to β-blockade for both HR lowering and reverse remodeling were randomized 2:1 double-blind to the HCN4 (hyperpolarization-activated cyclic nucleotide-gated potassium channel 4) channel inhibitor ivabradine or placebo for 24 weeks treatment while maintaining target doses of β-blockers.
JACC Heart Fail
March 2025
Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address:
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