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Bright and stable anti-counterfeiting devices with independent stochastic processes covering multiple length scales.
Nat Commun
January 2025
Department of Materials, Department of Bioengineering, Institute of Biomedical Engineering Imperial College London, London, UK.
Physical unclonable functions (PUFs) are considered the most promising approach to address the global issue of counterfeiting. Current PUF devices are often based on a single stochastic process, which can be broken, especially since their practical encoding capacities can be significantly lower than the theoretical value. Here we present stochastic PUF devices with features across multiple length scales, which incorporate semiconducting polymer nanoparticles (SPNs) as fluorescent taggants.
View Article and Find Full Text PDFDrug repositioning of mesalamine via supramolecular nanoassembly for the treatment of drug-induced acute liver failure.
Theranostics
January 2025
Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
Acute liver failure (ALF) is characterized by rapid hepatic dysfunction, primarily caused by drug-induced hepatotoxicity. Due to the lack of satisfactory treatment options, ALF remains a fatal clinical disease, representing a grand challenge in global health. For the drug repositioning to ALF of mesalamine, which is clinically approved for the treatment of inflammatory bowel disease (IBD), we propose a supramolecular prodrug nanoassembly (SPNs).
View Article and Find Full Text PDFThe impact of Parkinson's disease on striatal network connectivity and corticostriatal drive: An in silico study.
Netw Neurosci
December 2024
Science for Life Laboratory, Department of Computer Science, KTH Royal Institute of Technology, Stockholm, Sweden.
Striatum, the input stage of the basal ganglia, is important for sensory-motor integration, initiation and selection of behavior, as well as reward learning. Striatum receives glutamatergic inputs from mainly cortex and thalamus. In rodents, the striatal projection neurons (SPNs), giving rise to the direct and the indirect pathway (dSPNs and iSPNs, respectively), account for 95% of the neurons, and the remaining 5% are GABAergic and cholinergic interneurons.
View Article and Find Full Text PDFConstruction of a risk prediction model for isolated pulmonary nodules 5-15 mm in diameter.
Transl Lung Cancer Res
November 2024
Department of Pulmonary and Critical Care Medicine, Fuzhou General Hospital of Fujian Medical University, Dongfang Hospital of Xiamen University, The 900th Hospital of the Joint Logistic Support Force, People's Liberation Army of China, Fuzhou, China.
Article Synopsis
- - The study aimed to create a prediction model for assessing the risk of malignancy in solitary pulmonary nodules (SPNs) that are 5-15 mm in size, acknowledging limitations in current detection technologies.
- - A total of 417 patients were analyzed for clinical and imaging features, with key factors like smoking history, nodule characteristics, and specific signs being identified as significant in determining malignancy risks.
- - The developed model showed strong predictive performance, outperforming existing models, with an area under the curve (AUC) of 0.814 for the training cohort and 0.864 for the validation cohort, indicating its high clinical usefulness.
Parallel labeled-line organization of sympathetic outflow for selective organ regulation in mice.
Nat Commun
December 2024
Laboratory for Comparative Connectomics, RIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo, Japan.
The sympathetic nervous system is crucial for responding to environmental changes. This regulation is coordinated by the spinal sympathetic preganglionic neurons (SPNs), innervating both postganglionic neurons and the adrenal gland. Despite decades of research supporting the concept of selective control within this system, the neural circuit organization responsible for the output specificity remains poorly understood.
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