Purpose: Determine the epidemiology of intoxications in the emergency service medico-surgical.
Materials And Methods: The stady was retrospective and transversal from January 2002 to December 2006 in the service of medical surgical emergencies of the teaching hospital Gabriel Touré. Where included all patients admitted and presenting with acute poisoning. Chi2 test was used to compare our results and the level of significance set at p <0.05.
Results: Over 5 years, 365 cases of intoxication were collected on a total of 10997 admission with a prevalence of 3.32 %. Patients aged of 0-20 years accounted for 46.58% of cases. The female patients were predominant with 62.47 % of cases. Pupils and students predominated with 31.51 %. Antimalarials were found primarily at the base of poisoning with 32.33 % of cases of drug poisoning. The digestive tract was predominant with 97.81%.
Conclusion: The typical profile of acute poisoning is a young female pupil or student who took a voluntary drug substance.
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J Neurol
January 2025
Parkinson's Disease Research Clinic, Macquarie University, 75 Talavera Road, Sydney, NSW, 2109, Australia.
Impulse Control Disorders (ICDs) are increasingly recognized as a significant non-motor complication in Parkinson's disease (PD), impacting patients and their caregivers. ICDs in PD are primarily associated with dopaminergic treatments, particularly dopamine agonists, though not all patients develop these disorders, indicating a role for genetic and other clinical factors. Studies over the past few years suggest that the mesocorticolimbic reward system, a core neural substrate for impulsivity, is a key contributor to ICDs in PD.
View Article and Find Full Text PDFClin Pharmacokinet
January 2025
Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
Background And Objective: Psilocybin is currently being extensively studied as a potential therapeutic agent for multiple psychiatric disorders. Here, a systematic literature review of all published pharmacokinetic data on the pharmacologically active metabolite of psilocybin, psilocin, is presented.
Methods: The review includes clinical studies that reported pharmacokinetic data and/or parameters after psilocybin administration in humans.
Heliyon
January 2025
Optometry & Vision Science Research Group (OVSRG), School of Optometry, Aston University, Birmingham, UK.
Background: This study aimed to explore behaviour of practitioners in response to the COVID-19 pandemic, analysing the factors that influenced their decisions to resume professional practice post-lockdown and intention to adhere to COVID-19 protective measures.
Methods: A web-based cross-sectional survey targeting Italian practitioners was carried out to study the post lockdown behaviour and future intention to provide new contact lens (CL) fittings, and the use of protective measures. The survey also explored the dimensions of the Integrated Behavioural Model (IBM) and the Health Belief Model (HBM) to predict the intention to resume professional practice and to comply with protective measures respectively.
Kidney Int Rep
January 2025
Néphrologie, Hôpital Tenon, Sorbonne Université, Paris, France.
J Intensive Care
January 2025
Medical and Infectious Diseases, ICU, Hospital Bichat-Claude Bernard, Université Paris Cité, AP-HP, Paris, France.
Background: Sepsis-associated encephalopathy (SAE) may be worsened by early systemic insults. We aimed to investigate the association of early systemic insults with outcomes of critically ill patients with severe SAE.
Methods: We performed a retrospective analysis using data from the French OUTCOMEREA prospective multicenter database.
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