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File: /var/www/html/application/controllers/Detail.php
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Conformationally-restricted cyclic sulfones as potent and selective mTOR kinase inhibitors. | LitMetric
Novel conformationally-restricted mTOR kinase inhibitors with cyclic sulfone scaffold were designed. Synthesis and structure-activity relationship (SAR) studies are described with emphasis on optimization of the mTOR potency and selectivity against class I PI3Kα kinase. PF-05139962 was identified with excellent mTOR biochemical inhibition, cellular potency, kinase selectivity and in vitro ADME properties.
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conformationally-restricted cyclic
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