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Toxicity and Oxidative Stress Biomarkers in the Organs of Mice Treated with Mesoporous Polydopamine Nanoparticles Modified with Iron and Coated with Cancer Cell Membrane.
Int J Nanomedicine
November 2024
Laboratory of Environmental Research, Department of Toxicology, Poznan University of Medical Sciences, Poznań, Poland.
Purpose: Polydopamine nanoparticles (PDA NPs) have great potential in medicine. Their applications being widely investigated in cancer therapy, imaging, chemotherapy, photodynamic therapy (PDT), photothermal therapy (PTT), and tissue repair. The aim of our study was to assess the in vivo toxicity and changes in oxidative stress biomarkers in organs of animals treated with mesoporous PDA NPs modified with iron (MPDAFe NPs), coated with the cancer cell membrane and loaded with doxorubicin (DOX), and subsequently subjected to PTT.
View Article and Find Full Text PDFFunctional evidence that S-nitroso-L-cysteine may be a candidate carotid body neurotransmitter.
Neuropharmacology
March 2025
Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA; Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA; Functional Electrical Stimulation Center, Case Western Reserve University, Cleveland, OH, USA.
The primary objective of the present study is to provide further evidence that the endogenous S-nitrosothiol, S-nitroso-L-cysteine (L-CSNO), plays an essential role in signaling the hypoxic ventilatory response (HVR) in rodents. Key findings were that (1) injection of L-CSNO (50 nmol/kg, IV) caused a pronounced increase in frequency of breathing (Freq), tidal volume (TV) and minute ventilation (MV) in naïve C57BL/6 mice, whereas injection of D-CSNO (50 nmol/kg, IV) elicited minimal responses; (2) L-CSNO elicited minor responses in (a) C57BL/6 mice with bilateral carotid sinus nerve transection (CSNX), (b) C57BL/6 mice treated neonatally with capsaicin (CAP) to eliminate small-diameter C-fibers, and (c) C57BL/6 mice receiving continuous infusion of L-CSNO receptor antagonists, S-methyl-L-cysteine and S-ethyl-L-cysteine (L-SMC + L-SEC, both at 5 μmol/kg/min, IV); and (3) injection of S-nitroso-L-glutathione (L-GSNO, 50 nmol/kg, IV) elicited pronounced ventilatory responses that were not inhibited by L-SMC + L-SEC. Subsequent exposure of naïve C57BL/6 mice to a hypoxic gas challenge (HXC; 10% O, 90% N) elicited pronounced increases in Freq, TV and MV that were subject to roll-off.
View Article and Find Full Text PDFHybrid thermosensitive hydrogel/amniotic membrane structure incorporating S-nitrosothiol microparticles: potential uses for controlled nitric oxide delivery.
Int J Pharm
January 2025
Preventative Gynecology Research Center(PGRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Insufficient levels of nitric oxide may lead to chronic and acute wounds. Additionally, it is crucial that nitric oxide is prepared in a controlled-release manner due to its gaseous nature and short half-life. To address this issue, utilizing nitric oxide donors, particularly S-nitrosothiols such as S-nitrosoglutathione (GSNO), could efficiently overcome instability and aid in biomedical applications.
View Article and Find Full Text PDFNitric oxide-releasing self-healing hydrogel for antibacterial and antibiofilm efficacy against polymicrobial infection.
Future Microbiol
November 2024
College of Pharmacy, Pusan National University, Busandaehak-ro 63 beon-gil 2, Geumjeong-gu, Busan, 46241, Republic of Korea.
Bacterial infections and the formation of biofilms are currently key factors in the delay of wound healing. S-Nitroso glutathione (GSNO) is recognized as a nitric oxide (NO) donor that exhibits potent antibacterial and antibiofilm activities. However, some of the stability limitations of NO require it to be prepared pharmaceutically.
View Article and Find Full Text PDFDisrupted nitric oxide homeostasis impacts fertility through multiple processes including protein quality control.
Plant Physiol
December 2024
Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Plant fertility is fundamental to plant survival and requires the coordinated interaction of developmental pathways and signaling molecules. Nitric oxide (NO) is a small, gaseous signaling molecule that plays crucial roles in plant fertility as well as other developmental processes and stress responses. NO influences biological processes through S-nitrosation, the posttranslational modification of protein cysteines to S-nitrosocysteine (R-SNO).
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