AI Article Synopsis
- A new one-pot method was created that combines several chemical reactions: Overman rearrangement, ring-closing enyne metathesis, and a Diels-Alder reaction guided by hydrogen bonding.
- This process allows for the efficient creation of complex molecules with specific geometries, known as diastereomers, which have amino groups attached.
- The resulting compounds are functionalized tetralin and indene ring systems, which could be valuable for various applications in chemistry and pharmaceuticals.
Article Abstract
A one-pot tandem process involving an Overman rearrangement, ring closing enyne metathesis and a hydrogen bonding directed Diels-Alder reaction has been developed for the efficient diastereoselective synthesis of functionalised amino substituted tetralin and indene ring systems.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c2cc33649a | DOI Listing |
Publication Analysis
Top Keywords
tandem process
8
discovery multi-bond
4
multi-bond forming
4
forming four-step
4
four-step tandem
4
process construction
4
construction drug-like
4
drug-like polycyclic
4
polycyclic scaffolds
4
scaffolds one-pot
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!