Unlabelled: Several studies suggest that cytokines and neutrophils play an important role in the pathogenesis of acute pancreatitis (AP). The AIM OF THE STUDY was to assess the systemic release of proinflammatory cytokines and WBC (white blood cells) count with differential in patients with acute alcoholic pancreatitis (AAP) and to characterize the differences between patients with mild and severe forms of the disease.
Material And Methods: Thirty-five patients with the mild form of acute alcoholic pancreatitis (MAAP) were compared to 11 patients with severe acute alcoholic pancreatitis (SAAP). Serum levels of IL-6, IL-8, IL-12p40 and WBC differential count were measured every second day during the first week after admission.
Results: During the course of the study, the average level of IL-6 was significantly (p<0.05) higher in patients with SAAP than in patients with the mild form of the disease (MAAP). Serum levels of IL-8 and IL-12p40 on admission were higher in patients with SAAP than in patients with MAAP but the difference was not statistically significant. Of all the types of WBCs, neutrophils were significantly (p<0.05) elevated the entire time in SAAP patients when compared to patients with MAAP on 5th and 7th day from admission to hospital.
Conclusions: Patients with SAAP had significantly higher proinflammatory cytokine IL-6 levels and neutrophil counts than patients with MAAP. The results suggest that proliferation and overstimulation of this subset of leukocytes might contribute to the development of the systemic inflammatory response in patients with SAAP.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2478/v10035-012-0038-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Leptospirosis Causing Severe Acute Kidney Injury, Hyperbilirubinemia, and Thrombocytopenia: A Case Report.
Cureus
November 2024
Internal Medicine, Corewell Health, Royal Oak, USA.
Leptospirosis, an infection caused by the spirochete Leptospira and commonly attributed to the underdeveloped world, is frequently under-diagnosed in the United States. This report discusses the case of a 79-year-old male with no significant medical history who presented to the ED with recurrent falls. Initial laboratory results demonstrated severe acute kidney injury, hyperbilirubinemia, and thrombocytopenia.
View Article and Find Full Text PDFEvaluating data sharing statements in leading emergency medicine journals: A mixed methods review.
Am J Emerg Med
December 2024
Office of Medical Student Research, Oklahoma State University Center for Health Sciences, Tulsa, OK, United States; Department of Psychiatry and Behavioral Sciences, Oklahoma State University Center for Health Sciences, Tulsa, OK, United States.
Background: Emergency medicine remains as the front line of healthcare, providing acute care to a diverse population during urgent and critical moments. Our objective was to systematically quantify the prevalence of data sharing statements (DSS) in high-impact emergency medicine journals and assess their implementation by contacting corresponding authors who indicated data available upon request.
Methods: We conducted a cross-sectional analysis to identify the prevalence and content of data sharing statements in clinical studies published in high impact emergency medicine journals between 2018 and 2023, followed by a hierarchical logistic regression analysis to identify variables impacting the incorporation of data sharing statements into emergency medicine studies.
MRI appearance of Bochdalek's flower basket in a patient with bilateral hippocampus infarct.
Radiol Case Rep
February 2025
Department of Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Wardha, Maharashtra, India, 442001.
The occurrence of isolated bilateral hippocampus infarct is extremely rare and is thought to be associated with a number of etiologies, including ischemia, infection, paraneoplastic syndromes, seizures, drug addiction, etc. The presented manuscript depicts a case of a 28-year-old male patient who has been a chronic alcoholic for the past 4 years and, on imaging, was found to have a bilateral hippocampal infarct in isolation. Also, the manuscript presents the appearance of the magnetic resonance imaging (MRI) of Bochdalek's flower basket, which is an anatomical variant of the choroid plexus in the fourth ventricle.
View Article and Find Full Text PDFObjective: Aim: to find out the gender characteristics of oxidative mechanisms of liver damage in rats with ethanol hepatitis (EH).
Patients And Methods: Materials and Methods: The study was performed on 48 white male and female rats: 1 - control, 2 - acute EH (12,5 ml/kg of a 40% ethanol solution prepared on 5% solution of glucose for 7 days).The diene and triene conjugates (DC, TC), Schiff's bases (SB), TBA-active products (TBA-ap), activity of superoxide dismutase (SOD) and catalase (CAT) were determined in the blood serum.
Development and evaluation of a machine learning model for post-surgical acute kidney injury in active infective endocarditis.
Front Cardiovasc Med
December 2024
Chief of Cardiac Surgery, Peking Union Medical College Hospital, Beijing, China.
Introduction: Acute kidney injury (AKI) is notably prevalent after cardiac surgery for patients with active infective endocarditis. This study aims to create a machine learning model to predict AKI in this high-risk group, improving upon existing models by focusing specifically on endocarditis-related surgeries.
Methods: We analyzed medical records from 527 patients who underwent cardiac surgery for active infective endocarditis from January 2012 to December 2023.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!