Rationale: Source monitoring (SM) is a metacognitive process involved in making judgments about the origin of information by recruiting cognitive processes. Deficits in SM have been linked to positive symptoms of schizophrenia. We investigated whether certain neurocognitive functions - specifically attention, working memory, and organizational sequencing - were associated with SM in a sample of schizophrenia patients.
Methods: Attention (Auditory Continuous Performance Test), organizational sequencing (Trail-Making Test B-A), working memory (Digits Backward), and internal SM were assessed in 45 outpatients diagnosed with schizophrenia or schizoaffective disorder.
Results: Standard multiple regression analysis showed attention, working memory and organizational sequencing together predicted SM. Organizational sequencing was the only significant individual predictor, with better organizational sequencing ability being associated with better SM. Hierarchical regression analysis showed that working memory by itself did not result in a significant predictive model of SM, but adding organizational sequencing led to a significant change from the working memory model and resulted in a significant overall model, accounting for 26% of the variance in SM.
Conclusions: Neurocognitive functions were associated with SM in schizophrenia. Organizational sequencing, which requires an awareness of self-generated actions, predicted SM performance even after controlling for working memory.
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http://dx.doi.org/10.1016/j.psychres.2012.06.014 | DOI Listing |
Genes Dev
December 2024
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5T 3H7, Canada;
The nucleolus is a major subnuclear compartment where ribosomal DNA (rDNA) is transcribed and ribosomes are assembled. In addition, recent studies have shown that the nucleolus is a dynamic organizer of chromatin architecture that modulates developmental gene expression. rDNA gene units are assembled into arrays located in the p-arms of five human acrocentric chromosomes.
View Article and Find Full Text PDFNucleic Acids Res
January 2025
Institute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, 10257, Lithuania.
The expansion of single-cell analytical techniques has empowered the exploration of diverse biological questions at the individual cells. Droplet-based single-cell RNA sequencing (scRNA-seq) methods have been particularly widely used due to their high-throughput capabilities and small reaction volumes. While commercial systems have contributed to the widespread adoption of droplet-based scRNA-seq, their relatively high cost limits the ability to profile large numbers of cells and samples.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre "Kurchatov Institute", Gatchina 188300, Russia.
Arthrogryposis, which represents a group of congenital disorders, includes various forms. One such form is amyoplasia, which most commonly presents in a sporadic form in addition to distal forms, among which hereditary cases may occur. This condition is characterized by limited joint mobility and muscle weakness, leading to limb deformities and various clinical manifestations.
View Article and Find Full Text PDFBMC Genomics
January 2025
Department of Animal Sciences, Purdue University, 270 S. Russell Street, West Lafayette, IN, 47907, USA.
Background: The profitability of the beef industry is directly influenced by the fertility rate and reproductive performance of both males and females, which can be improved through selective breeding. When performing genomic analyses, genetic markers located on the X chromosome have been commonly ignored despite the X chromosome being one of the largest chromosomes in the cattle genome. Therefore, the primary objectives of this study were to: (1) estimate variance components and genetic parameters for eighteen male and five female fertility and reproductive traits in Nellore cattle including X chromosome markers in the analyses; and (2) perform genome-wide association studies and functional genomic analyses to better understand the genetic background of male and female fertility and reproductive performance traits in Nellore cattle.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
State Key Laboratory of Mariculture Breeding, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, China; Fujian Key Laboratory of Genetics and Breeding of Marine Organisms, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, China. Electronic address:
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